Chemotherapy-Induced Neuropathic Pain

Robert B. Raffa, Richard Langford, Joseph V. Pergolizzi, Jr., Frank Porreca, Ronald J. Tallarida

July 24, 2012 by CRC Press
Reference - 233 Pages - 22 B/W Illustrations
ISBN 9781439862186 - CAT# K12881


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  • Addresses the issues of chemotherapy-induced neuropathic pain
  • Covers basic science and clinical research
  • Explains the physiology of normal and neuropathic pain
  • Describes the effect of various cytotoxic agents on different nerves
  • Provides insight into drug discovery efforts
  • Explores practical pain management strategies, tactics, and options


There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.

Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.