Chemistry and Biochemistry of Flavoenzymes summarizes the present knowledge of the chemical and physical properties of free flavin, modified flavins occurring in nature, and deazaflavin. This information forms the fundamental basis for understanding the catalytic properties of flavoenzymes. Flavoproteins involved in transport, electron transfer, oxidation, dehydrogenation and hydroxylation reactions are discussed with respect to their biochemical and biophysical properties. The book presents the catalytic mechanisms of the flavoproteins in detail and, where available, three-dimensional structures and molecular biology data are included. The medical aspects of free and protein-bound flavin are also briefly discussed. Chemistry and Biochemistry of Flavoenzymes is an essential reference source for chemists, biochemists, toxicologists, biologists, pharmacologists, and researchers in the pharmaceutical industry.
Table of Contents
1. Flavin-Dependent Monooxygenases with Special Reference to p-Hydroxybenzoate Hydroxylase 2 .The Structure of p-Hydroxybenzoate Hydroxylase 3. Phenol Hydroxylase 4. The Multisubstrate FAD-Containing Monooxygenase 5. A Steroid Ketone Monooxygenase from Cylindrocarpon Radicicola 6. The Mechanism of Bacterial Bioluminescence 7. Flavocytochrome b2 8. L-Lactate Oxidase 9. Nitroreductases 10. Ferredoxin- NADP+ Oxidoreductase 11. Enoate Reductase H. Simon 12. NADPH-Adrenodoxin Oxidoreductase 13. Covalent Flavoproteins 14. Flavocytochrome 15. The Biochemical Properties and Structure of Trimethylamine Dehydrogenase 16. Role of the Covalent and Noncovalent Flavins in Sarcosine Oxidase 17. Monoamine Oxidases 18. Electron-Transferring Flavoproteins