This thoroughly revised and updated reference addresses the drugs and chemicals causing malformations and congenital anomalies in the human fetus-comprehensively reviewing experimental studies in animals and clinical data on human development, primarily in the organogenesis period. Addressing current public health concerns over teratogens, Chemically Induced Birth Defects, Third Edition covers and condenses the 2500 new publications on developmental toxicology that appear every year.
Provides comprehensive identification of teratogens by chemical, generic, and trade names.
Chemically Induced Birth Defects, Third Edition
discusses the interrelation of over 4100 chemicals in current use, still in the experimental stage, or now obsolete
covers recently available drugs, such as misoprostol and fluconazole
utilizes the latest Good Laboratory Practices-conducted studies to evaluate specific agents
investigates up-to-the-minute impairments of maternal homeostasis that may lead to teratogenesis
surveys chemicals by use, distinguishing medicinals from industrial chemicals
elucidates recent research on chemicals linked to endocrine disruption
Containing over 10,000 citations from the literature, Chemically Induced Birth Defects, Third Edition deserves a place on the bookshelves of all toxicologists, teratologists, pediatricians, obstetricians, gynecologists, environmentalists, biochemists, oncologists, pharmacologists, endocrinologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.
Table of Contents
Principles of Teratogenesis Applicable to Drug and Chemical Exposure
Universal praise for the previous editions…
…a remarkable work, which will probably prove the most complete readily available reference book for some years to come.
"-British Journal of Obstetrics and Gynaecology
"…an excellent and welcome summary of the literature on studies in humans and animals of exposure to drugs and chemicals.
"-Journal of the American Medical Association
"…an excellent introduction to the principles of teratogenesis….
"-Journal of Pharmacy and Pharmacology
"…'Schardein' has been a standard work in this field since its first publication [in 1976]….
…comprehensive…provides an enormous number of references….
Use this book with benefit as a catalogue and an initial lead to the literature.
"-Human & Experimental Toxicology
"…a wonderful resource….
…Those of us who do a lot of counseling or writing on developmental toxicity cannot afford to be without this book.
Prepublication praise for the Third Edition"…
…The immensity and completeness of the bibliography and the extensiveness of the index makes the book a necessity for teratologists who wish to become familiar with many aspects of environmental reproductive risks. Besides presenting rather complete reviews of the literature…Schardein has prepared numerous tables that summarize these reproductive effects succinctly and with clarity.
"-from the Foreword by Dr. Robert L. Brent, Head, Laboratory of Clinical and Environmental Teratology, Alfred I. duPont Hospital for Children, Wilmington, Delaware
"…an excellent compilation.
"- Indian Journal of Toxicology