This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
Table of Contents
Chemical Approaches to Rational Drug Design
Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase, J.R. McCarthy and P.S. Sunkara.
The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors, A. Stern.
The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model, R.M. Keenan, J. Weinstock, J.C. Hempel, J.M. Samanen, D.T. Hill, N. Aiyar, E.H. Ohlstein, and R.M. Edwards.
Endothelin Structure and Development of Receptor Antagonists, A.M. Doherty.
Molecular Targeting Chemistry in Rational Drug Design, A. Fritzberg, L. Gustavson, M. Hylarides, and J. Reno.
Structural Approaches to Rational Drug Design
The Role of X-Ray Crystallography in Structure-Based Rational Drug Design, A. McPherson.
Biocomputational Approaches to Protein-Based Drug Design, K. Prammer, M. Weiner, and T. Kieber-Emmons.
Architecture and Design of Zinc Protein-Ligand Complexes, D.W. Christianson and A.M. Khoury Christianson.
Design of Immunomodulatory Peptides Based on Active Site Structures, A.B. Mukherjee and L. Miele.