Chemical Approaches to the Synthesis of Peptides and Proteins

1st Edition

Paul Lloyd-Williams, Fernando Albericio, Ernest Giralt

CRC Press
Published April 23, 1997
Reference - 304 Pages
ISBN 9780849391422 - CAT# 9142
Series: New Directions in Organic & Biological Chemistry

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Summary

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications.
This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

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