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Chapman & Hall/CRC Biostatistics Series


About the Series

The primary objectives of the Chapman & Hall/CRC Biostatistics Series are to provide useful reference books for researchers and scientists in academia, industry, and government, and also to offer textbooks for undergraduate and graduate courses in the area of biostatistics and bioinformatics. The book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics and bioinformatics, such as those in biological and biomedical research.

The scope of the series is wide, including applications of statistical methodology in biology, epidemiology, genetics, pharmaceutical science and clinical trials, public health, and medicine. The series is committed to providing easy to understand, state-of-the-art references and textbooks. In each volume, statistical concepts and methodologies will be illustrated through real world examples whenever possible.

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Statistical Approaches in Oncology Clinical Development

Statistical Approaches in Oncology Clinical Development

Forthcoming

Satrajiit Roychoudhury, Soumi Lahiri
May 01, 2018

Oncology is a rapidly developing area in medical science. A significant investment in terms of costs, resources and time is required for oncology drug development. Understanding of the challenges at all stages is vital for a successful drug launching. The purpose of this book is to provide an...

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Forthcoming

Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 13, 2017

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...

Medical Biostatistics, Fourth Edition

Medical Biostatistics, Fourth Edition

Forthcoming

Abhaya Indrayan, Rajeev Kumar Malhotra
December 01, 2017

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Fourth Edition focuses on the statistical aspects ofmedicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. This edition includes more topics in order to fill...

Statistical Topics in Health Economics and Outcomes Research

Statistical Topics in Health Economics and Outcomes Research

Forthcoming

Demissie Alemayehu, PhD, Joseph C. Cappelleri, PhD, Birol Emir, PhD, Kelly H. Zou, PhD, Pstat
November 29, 2017

With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to...

Randomization, Masking, and Allocation Concealment

Randomization, Masking, and Allocation Concealment

Vance Berger
October 27, 2017

Randomization, Masking, and Allocation Concealment is indispensable for any trial researcher who wants to use state of the art randomization methods, and also wants to be able to describe these methods correctly. Far too often the subtle nuances that distinguish proper randomization from flawed...

Sample Size Calculations in Clinical Research, Third Edition

Sample Size Calculations in Clinical Research, Third Edition

Shein-Chung Chow, Jun Shao, Hansheng Wang, Yuliya Lokhnygina
August 30, 2017

Praise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size...

Quantitative Methods for HIV/AIDS Research

Quantitative Methods for HIV/AIDS Research

Cliburn Chan, Michael G. Hudgens, Shein-Chung Chow
August 15, 2017

Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research;...

Bayesian Methods for Repeated Measures

Bayesian Methods for Repeated Measures

Lyle D. Broemeling
August 01, 2017

Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for...

Cluster Randomised Trials, Second Edition

Cluster Randomised Trials, Second Edition

Richard J. Hayes, Lawrence H. Moulton
June 27, 2017

Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against...

Clinical Trial Optimization Using R

Clinical Trial Optimization Using R

Alex Dmitrienko, Erik Pulkstenis
June 07, 2017

Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as...

Clinical Trial Data Analysis Using R and SAS, Second Edition

Clinical Trial Data Analysis Using R and SAS, Second Edition

Ding-Geng (Din) Chen, Karl E. Peace, Pinggao Zhang
May 03, 2017

Review of the First Edition "The goal of this book, as stated by the authors, is to fill the knowledge gap that exists between developed statistical methods and the applications of these methods. Overall, this book achieves the goal successfully and does a nice job. I would highly recommend it …The...

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials

Toshiro Tango
February 16, 2017

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The...

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