The primary objectives of the Chapman & Hall/CRC Biostatistics Series are to provide useful reference books for researchers and scientists in academia, industry, and government, and also to offer textbooks for undergraduate and graduate courses in the area of biostatistics and bioinformatics. The book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics and bioinformatics, such as those in biological and biomedical research.
The scope of the series is wide, including applications of statistical methodology in biology, epidemiology, genetics, pharmaceutical science and clinical trials, public health, and medicine. The series is committed to providing easy to understand, state-of-the-art references and textbooks. In each volume, statistical concepts and methodologies will be illustrated through real world examples whenever possible.
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R
Shu-Kay Ng, Liming Xiang, Kelvin Kai Wing Yau
November 30, 2018
Mixture Modelling for Medical and Health Sciences provides a direct connection between theoretical developments in mixture modelling and their applications in real world problems. The book describes the development of the most important concepts through comprehensive analyses of real and practical...
Seth Berry, Russell Reeve
November 30, 2018
Iftekhar Khan, Zahid Bashir, Ralph Crott
September 01, 2018
This is the first book on the design and analysis of not only clinical trials but also how observational non-interventional data using clinical data is applied to economic evaluation and re-imbursement in the context of Cancer. The authors assume the reader has no knowledge of economic evaluation...
Jie Chen, Joseph Heyse, Tze Leung Lai
July 09, 2018
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in...
Satrajiit Roychoudhury, Soumi Lahiri
July 01, 2018
Statistical Challenges in Oncology Clinical Development presents an overview of statistical considerations in oncology clinical trials, including both early and late phase of development. It illustrates how the novel statistical methods can enrich the design and analysis of modern oncology trials....
July 01, 2018
Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and...
June 20, 2018
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with...
Lyle D. Broemeling
June 01, 2018
Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for...
Paddy Farrington, Heather Whitaker, Yonas Ghebremichael Weldeselassie
May 02, 2018
Self-Controlled Case Series Studies: A Modelling Guide with R provides the first comprehensive account of the self-controlled case series (SCCS) method, a statistical technique for investigating associations between outcome events and time-varying exposures. The method only requires information...
Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 13, 2017
An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...
Abhaya Indrayan, Rajeev Kumar Malhotra
December 06, 2017
Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Fourth Edition focuses on the statistical aspects ofmedicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. This edition includes more topics in order to fill...
Demissie Alemayehu, PhD, Joseph C. Cappelleri, PhD, Birol Emir, PhD, Kelly H. Zou, PhD, Pstat
November 28, 2017
With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to...