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Chapman & Hall/CRC Biostatistics Series


About the Series

The primary objectives of the Chapman & Hall/CRC Biostatistics Series are to provide useful reference books for researchers and scientists in academia, industry, and government, and also to offer textbooks for undergraduate and graduate courses in the area of biostatistics and bioinformatics. The book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics and bioinformatics, such as those in biological and biomedical research.

The scope of the series is wide, including applications of statistical methodology in biology, epidemiology, genetics, pharmaceutical science and clinical trials, public health, and medicine. The series is committed to providing easy to understand, state-of-the-art references and textbooks. In each volume, statistical concepts and methodologies will be illustrated through real world examples whenever possible.

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Mixture Modelling for Medical and Health Sciences

Mixture Modelling for Medical and Health Sciences

Forthcoming

Shu-Kay Ng, Liming Xiang, Kelvin Kai Wing Yau
February 15, 2019

Mixture Modelling for Medical and Health Sciences provides a direct connection between theoretical developments in mixture modelling and their applications in real world problems. The book describes the development of the most important concepts through comprehensive analyses of real and practical...

Statistical Approaches in Oncology Clinical Development: Current Paradigm and Methodological Advancement

Statistical Approaches in Oncology Clinical Development: Current Paradigm and Methodological Advancement

Forthcoming

Satrajit Roychoudhury, Soumi Lahiri
November 26, 2018

Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and...

Platform Trial Designs in Drug Development: Umbrella Trials and Basket Trials

Platform Trial Designs in Drug Development: Umbrella Trials and Basket Trials

Forthcoming

Zoran Antonijevic, Robert A. Beckman
November 13, 2018

Platform Trials in Drug Development: Umbrella Trials and Basket Trials Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to...

Medical Product Safety Evaluation: Biological Models and Statistical Methods

Medical Product Safety Evaluation: Biological Models and Statistical Methods

Forthcoming

Jie Chen, Joseph Heyse, Tze Leung Lai
August 31, 2018

Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in...

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

Jianrong Wu
June 18, 2018

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with...

Bayesian Methods for Repeated Measures

Bayesian Methods for Repeated Measures

Lyle D. Broemeling
June 01, 2018

Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for...

Self-Controlled Case Series Studies: A Modelling Guide with R

Self-Controlled Case Series Studies: A Modelling Guide with R

Paddy Farrington, Heather Whitaker, Yonas Ghebremichael Weldeselassie
May 02, 2018

Self-Controlled Case Series Studies: A Modelling Guide with R provides the first comprehensive account of the self-controlled case series (SCCS) method, a statistical technique for investigating associations between outcome events and time-varying exposures. The method only requires information...

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 13, 2017

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...

Medical Biostatistics

Medical Biostatistics

Abhaya Indrayan, Rajeev Kumar Malhotra
December 06, 2017

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Fourth Edition focuses on the statistical aspects ofmedicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. This edition includes more topics in order to fill...

Statistical Topics in Health Economics and Outcomes Research

Statistical Topics in Health Economics and Outcomes Research

Demissie Alemayehu, PhD, Joseph C. Cappelleri, PhD, Birol Emir, PhD, Kelly H. Zou, PhD, Pstat
November 28, 2017

With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to...

Randomization, Masking, and Allocation Concealment

Randomization, Masking, and Allocation Concealment

Vance Berger
October 26, 2017

Randomization, Masking, and Allocation Concealment is indispensable for any trial researcher who wants to use state of the art randomization methods, and also wants to be able to describe these methods correctly. Far too often the subtle nuances that distinguish proper randomization from flawed...

Sample Size Calculations in Clinical Research

Sample Size Calculations in Clinical Research

Shein-Chung Chow, Jun Shao, Hansheng Wang, Yuliya Lokhnygina
August 30, 2017

Praise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size...

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