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Chapman & Hall/CRC Biostatistics Series


About the Series

The primary objectives of the Chapman & Hall/CRC Biostatistics Series are to provide useful reference books for researchers and scientists in academia, industry, and government, and also to offer textbooks for undergraduate and graduate courses in the area of biostatistics and bioinformatics. The book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics and bioinformatics, such as those in biological and biomedical research.

The scope of the series is wide, including applications of statistical methodology in biology, epidemiology, genetics, pharmaceutical science and clinical trials, public health, and medicine. The series is committed to providing easy to understand, state-of-the-art references and textbooks. In each volume, statistical concepts and methodologies will be illustrated through real world examples whenever possible.

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Mathematical and Statistical Skills in the Biopharmaceutical Industry: A Pragmatic Approach

Mathematical and Statistical Skills in the Biopharmaceutical Industry: A Pragmatic Approach

Forthcoming

Arkadiy Pitman, Oleksandr Sverdlov, L. Bruce Pearce
September 30, 2018

This book will discuss an integral, pragmatic approach to solving day-to-day problems relevant to biostatistics function in the pharmaceutical industry. It will emphasize the importance of logical systematic thinking, clear problem formulation and answering research questions in selected terms. The...

Medical Product Safety Evaluation: Biological Models and Statistical Methods

Medical Product Safety Evaluation: Biological Models and Statistical Methods

Forthcoming

Jie Chen, Joseph Heyse, Tze Leung Lai
July 09, 2018

Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in...

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects

Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects

Forthcoming

Oleksandr Sverdlov
July 01, 2018

Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and...

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

Forthcoming

Jianrong Wu
June 05, 2018

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with...

Self-Controlled Case Series Studies: A Modelling Guide with R

Self-Controlled Case Series Studies: A Modelling Guide with R

Forthcoming

Paddy Farrington, Heather Whitaker, Yonas Ghebremichael Weldeselassie
May 02, 2018

"The self-controlled case series has emerged as a key methodology for studying the effects of healthcare interventions. The overall literature around the self-controlled case series has exploded in recent years and this important and timely book pulls it all together in an effective and clear...

Bayesian Methods for Repeated Measures

Bayesian Methods for Repeated Measures

Lyle D. Broemeling
April 01, 2018

Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for...

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 13, 2017

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...

Medical Biostatistics, Fourth Edition

Medical Biostatistics, Fourth Edition

Abhaya Indrayan, Rajeev Kumar Malhotra
December 06, 2017

Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Fourth Edition focuses on the statistical aspects ofmedicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. This edition includes more topics in order to fill...

Statistical Topics in Health Economics and Outcomes Research

Statistical Topics in Health Economics and Outcomes Research

Demissie Alemayehu, PhD, Joseph C. Cappelleri, PhD, Birol Emir, PhD, Kelly H. Zou, PhD, Pstat
November 28, 2017

With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to...

Randomization, Masking, and Allocation Concealment

Randomization, Masking, and Allocation Concealment

Vance Berger
October 26, 2017

Randomization, Masking, and Allocation Concealment is indispensable for any trial researcher who wants to use state of the art randomization methods, and also wants to be able to describe these methods correctly. Far too often the subtle nuances that distinguish proper randomization from flawed...

Sample Size Calculations in Clinical Research, Third Edition

Sample Size Calculations in Clinical Research, Third Edition

Shein-Chung Chow, Jun Shao, Hansheng Wang, Yuliya Lokhnygina
August 30, 2017

Praise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size...

Quantitative Methods for HIV/AIDS Research

Quantitative Methods for HIV/AIDS Research

Cliburn Chan, Michael G. Hudgens, Shein-Chung Chow
August 15, 2017

Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research;...

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