Cellular and Molecular Toxicology and In Vitro Toxicology

Daniel Acosta

July 14, 2017 by CRC Press
Reference - 176 Pages
ISBN 9781138506077 - CAT# K39566
Series: CRC Press Revivals

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Features

  • In vitro experimental models to evaluate toxicity of xenobiotics
  • Cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines
  • Vascular toxins and their biochemical effects
  • Most up-to-date information on toxicity of selected well-known drugs and chemicals
  • Summary

    This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

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