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Cellular and Molecular Mechanisms of Toxic Action


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Pore-forming Peptides and Protein Toxins

Pore-forming Peptides and Protein Toxins

1st Edition

Gianfranco Menestrina, M. Dalla Sera
January 30, 2003

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell...

Chimeric Toxins: Mechanisms of Action and Therapeutic Applications

Chimeric Toxins: Mechanisms of Action and Therapeutic Applications

1st Edition

Haya Lorberboum-Galski, Philip Lazarovici
May 30, 2002

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as...

Secretory Systems and Toxins

Secretory Systems and Toxins

1st Edition

Michal Linial, Alfonso Grasso, Phillip Lazarovici
October 20, 1998

This volume deals with the relationships between toxins and one of the most fundamental processes in any living cell - the secretory cycle. The reader will find up-to-date information on secretion, generated by experts in this fast evolving field. In the last decade extensive molecular and cellular...

Toxins and Signal Transduction

Toxins and Signal Transduction

1st Edition

Yehuda Gutman, Philip Lazarovici
May 22, 1997

Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological...

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