Cellular Immune Mechanisms and Tumor Dormancy

T. H. M. Stewart, E. Frederick Wheelock

July 13, 2017 by CRC Press
Reference - 384 Pages
ISBN 9781138104990 - CAT# K34989
Series: CRC Press Revivals


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  • Presents a multidisciplinary approach to examine tumor dormancy
  • Provides evidence that immunization of animals can lead to the initiation and maintenance of the tumor dormant state
  • Identified parallels between animals and humans regarding events or drugs that down regulate the cellular immune control of dormancy, allowing renewed growth of dormant tumors
  • Provides evidence that patients with non-small cell lung cancer have dormant tumor cells that showed renewed growth following immunosuppression
  • Summary

    Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, and whole blood transfusion is presented to show the vulnerability of cellular mechanisms maintaining dormancy. The potential for increasing the incidence of dormancy in micro metastases is also shown for non-small cell lung cancer, lymphoma, and leukemia. Cellular Immune Mechanisms and Tumor Dormancy is an important reference volume that will benefit researchers from many disciplines, including immunologists, pathologists, surgeons, and clinicians


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