Carotenoids and Retinal Disease

John T. Landrum, John Nolan

October 18, 2013 by CRC Press
Reference - 272 Pages - 44 B/W Illustrations
ISBN 9781466502048 - CAT# K14416

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Features

  • Provides up-to-date information on the importance of carotenoids in eye health
  • Describes the nature and distribution of carotenoids in the macula and the epidemiology that links them to ocular health
  • Focuses on AMD (age-related macular degeneration), the leading cause of severe vision loss and legal blindness in adults over 60 in developed countries, as well as other retinal diseases
  • Explains the presence of several chemically different carotenoids in the retina and research indicating they also function differently
  • Discusses xanthophylls and their uptake from the diet, transport in the body, and role in protection against photooxidation
  • Includes black-and-white and color figures and photographs that reinforce concepts of retina topography, visual processing, genetic and cell signal pathways, disease etiopathogenesis, and epidemiology

Summary

The macular carotenoids play key roles in eye health and retinal disease. Age-related macular degeneration (AMD), the most common cause of acquired blindness in much of the world, is associated with low levels of macular pigment. Macular pigment is also essential for enhancing visual performance by reducing glare disability and improving photostress recovery. Carotenoids and Retinal Disease presents an up-to-date, thorough volume devoted to the chemistry, pathobiology, visual science, and medical and public health significance of the macular carotenoids.

With contributions from an international group of leading experts, this book covers a range of topics, from macular anatomy to clinical trials. It begins with a chapter tracing the discovery of macular pigment through the more recent functional recognition of carotenoids. The text covers AMD risk factors, epidemiology, pathogenesis, and classifications. It reviews evidence from epidemiological studies of relationships between AMD and the carotenoids lutein, zeaxanthin, and meso-zeaxanthin, as well as evidence from clinical trials on the effects of macular carotenoid supplementation in subjects with AMD and normal subjects.

The book explores the use of molecular genetics in studying macular pigment and AMD pathogenesis; bioavailability of macular pigment; functions of lutein, zeaxanthin, and meso-zeaxanthin; and the identification of macular carotenoid binding proteins involved in pigment uptake and transport. It also covers xanthophyll–membrane interactions, and the macular carotenoids in human serum and their capacity to protect against AMD. Further, the implications of light distribution on the retina for AMD are discussed. Advancing our understanding of how the macular carotenoids enhance vision and prevent vision loss, this book provides a valuable reference for researchers and clinicians involved in the treatment and prevention of retinal disease.