Illustrating the development and determinants of possible plaque rupture, Cardiovascular Plaque Rupture provides an in-depth review of the pathology, etiology, cellular and molecular biology, diagnosis, and treatment of plaque in the cardiovascular system-exploring the roles of physical stress, inflammation, and infectious agents on the growth of cardiovascular disease.
Characterize and identify vulnerable plaque using novel imaging modalities and modifications of existing invasive and noninvasive technologies!
Containing recent data on preventive gene therapy and antibiotic stabilization of plaque, >Cardiovascular Plaque Rupture considers
serine proteinase and metalloproteinase inhibitors in the prevention of plaque rupture
lipid lowering to stabilize plaque
clinical trial designs to demonstrate therapeutic prevention of plaque rupture
Discussing current methods of plaque assessment, including intravascular ultrasound and elastography, in vivo spectroscopic analysis, optical coherence tomography, thermography, and magnetic resonance imaging, Cardiovascular Plaque Rupture is an indispensable guide for cardiologists, vascular and cardiac surgeons, radiologists, vascular biologists, endocrinologists, and fellows, residents, and medical school students in these disciplines.
Table of Contents
Background and Pathophysiology
Development of the Atherosclerotic Plaque
Joan W. Berman, Marwan Kazimi, and Harry Ma
Clinical and Pathological Correlates
Renu Virmani, Allen P. Burke, Andrew Farb, and Frank D. Kolodgie
The Role of Inflammation in Plaque Rupture
Anton E. Becker and Allard C. van der Wal
Molecular Mechanisms of Plaque Weakening and Disruption
Zorina S. Galis
Epidemiological Evidence for Inflammation in Plaque Rupture
Russell P. Tracy
Role of Mechanical Stress in Plaque Rupture: Mechanical and Biological Interactions