1st Edition
Cardiovascular Diseases Nutritional and Therapeutic Interventions
With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases.
Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect.
Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.
Part I: Epidemiological Study of Heart Disease
Epidemiology of Cardiovascular Disease
Salim S. Abunnaja and Juan A. Sanchez
Part II: Epigenetic Modifications in Arterial and Heart Diseases
Epigenetics of Atherosclerosis: Current Insights and Future Perspectives
Lucia Migliore and Maria Grazia Andreassi
Genetic and Epigenetic Basis of Myocardial Ischemia and Reperfusion Injury: Protection by Dietary Antioxidants and Chromatin-Modifying Compounds
Tom C. Karagiannis, Katherine Ververis, and Paul V. Licciardi
Attenuation of Myocardial Ischaemia-Reperfusion Injury by Probiotic Bacteria
Paul V. Licciardi, Katherine Ververis, Zheng Q. Toh, and Tom C. Karagiannis
Part III: Cardiovascular Disease
Lipid Regulation of Cardiac Ion Channels in Heart Disease
Lixia Yue, Zhichao Yue, and Jia Xie
Arginine, Tetrahydrobiopterin, and Nitric Oxide in Myocardial Protection
Murugesan Velayutham, Lawrence J. Druhan, and Arturo J. Cardounel
Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury
Tuanzhu Ha, Li Liu, Jim Kelley, David Williams, and Chuanfu Li
Aging, Nutrients, and Endogenous Stem Cell Populations
Ewa K. Zuba-Surma, Harold Elias, and Buddhadeb Dawn
Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis
Hongyan Zhu and Guo-Chang Fan
Doxorubicin-Induced Cardiomyopathy and Benefits from Vitamin C
Ana Ludke, Gauri Akolkar, Gunjan Bajpai, Neelam Khaper, and Pawan K. Singal
Hypoxic Preconditioning of Stem Cells to Treat Myocardial Infarction
Simi M. Chacko and Periannan Kuppusamy
Diabetes-Associated Cardiomyopathy and Cell Therapy
Edith Hochhauser, Michael Morozov, and Michael Arad
Part IV: Nutritional and Other Therapeutic Interventions for CVD
Pluripotent Stem Cell Therapy for Cardiac Regeneration
Kiwon Ban, Jaemin Byun, Sangsung Kim, Sukwon Koh, and Young-Sup Yoon
Nanotechnology and Cardiovascular Diseases
Kannan Badri Narayanan and Natarajan Sakthivel
Heart-Healthy Diet: "The Art and Science of Perfecting the Plate"
S. Sivasankaran
Nutritional Therapy in the Treatment of Oxidative-Stress-Induced Heart Disease
Yen-Chun Ho, Meng-Ling Wu, and Shaw-Fang Yet
Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease
Hajime Otani
Alcohol and Heart Health: Is the Preconditioning Effect of Wine Drinking Related to Alcohol-Induced Changes in Cellular Fatty Acid Profile?
Joël de Leiris, Stéphane Tanguy, and François Boucher
Antioxidative Compounds: Description and Evidence of Clinical Relevance
Thomas F. Whayne, Jr.
Garlic in Cardiovascular Health: Winnowing the Fact from Artifacts
Sanjay K. Banerjee and Subir K. Maulik
Resveratrol Emerges As a Miracle Cardioprotective Phytochemical Polyphenol and Nutraceutical
Vaithinathan Selvaraju, Mandip Joshi, Sainath R. Kotha, Narasimham L. Parinandi, and Nilanjana Maulik
Potent Beneficial Effects of Vegetables and Fruits of Cardiovascular Diseases
Namasivayam Nalini and Jesudoss Victor Antony Santiago
Phosphodiesterase-5 Inhibitors in Cardioprotection
Mahesh Thirunavukkarasu and Murugavel Ponnusamy
Flaxseed and Its Components in Coronary Artery and Peripheral Vascular Disease
Kailash Prasad
Flaxseed and Blood Pressure
Kailash Prasad
Curcumin and Cardiovascular Diseases
Sayantan Jana and Snehasikta Swarnakar
Effect of Fruit and Vegetable Intake on CVD Risk Factors in Humans
Lars O. Dragsted
Melon for Cardiovascular Health
Shubin K. Saha and Sibu P. Saha
Botanicals as Angiotensin Converting Enzyme Inhibitors Useful in Hypertension
Pulok K. Mukherjee, Sushil Kumar Chaudhary, Neelesh K. Nema, and B.P. Saha
Yoga, Meditation, and Healthy Heart: Principles and Evidence
Sasidharan Bijulal
Index
Biography
Nilanjana Maulik, Ph.D., FAHA, is a professor in the Department of Surgery, University of Connecticut Medical Center, Farmington, Connecticut. She is also a faculty member of the Cell Biology Graduate Program since 2004 at the University of Connecticut Health Center. Professor Maulik’s research focuses on the molecular mechanism of myocardial angiogenesis, ischemia/reperfusion injury, apoptosis, and on the development of cardioprotective strategies, diabetic heart failure, peripheral artery disease, and wound healing. She has published almost 180 original peer-reviewed articles, 35 book chapters, and has edited a book related to epigenetics and human disease.