Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis

1st Edition

Stephen L. George, Xiaofei Wang, Herbert Pang

Chapman and Hall/CRC
May 12, 2019 Forthcoming
Reference - 454 Pages - 60 B/W Illustrations
ISBN 9780367261177 - CAT# K424732
Series: Chapman & Hall/CRC Biostatistics Series

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Summary

Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials.

The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.

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