Calcium Entry Channels in Non-Excitable Cells

Summary

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Table of Contents

Electrophysiological Methods for Recording CRAC and TRPV5/6 Channels

J. Ashot Kozak and Grigori Rychkov

Studies of Structure-Function and Subunit Composition of Orai/STIM Channel

Marc Fahrner, Rainer Schindl, and Christoph Romanin

Signaling ER Store Depletion to Plasma Membrane Orai Channels

Aparna Gudlur and Patrick Hogan

Modulation or Orai1 and STIM1 by Cellular Factors

Jin Seok Woo, Sonal Srikanth, and Yousang Gwack

CRAC Channels and Ca2+-Dependent Gene Expression

Yi-Chun Yeh and Anant B. Parekh

Function of Orai/STIM Proteins Studied in Transgenic Animal Models

Masatsugu Oh-Hora and Xiuyuan Lu

Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET Approaches

Yandong Zhou, Youjun Wang, and Donald L. Gill

Optogenetic Approaches to Control Calcium Entry in Nonexcitable Cells

Lian He, Qian Zhang, Yubin Zhou, and Yun Huang

Regulation of Orai/STIM Channel Activities by pH

Albert S. Yu, Zhichao Yue, Jianlin Feng, and Lixia Yue

Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ Signaling

Klaus Groschner, Niroj Shrestha, and Nicola Fameli

Store-Independent orai Channels Regulated by STIM

Xuexin Zhang, Maxime Gueguinou, and Mohamed Trebak

Regulation and Role of Store-Operated Ca2+ Entry in Cellular Proliferation

Rawad Hodeify, Fang Yu, Raphael Courjaret, Nancy Nader, Maya Dib, Lu Sun, Ethel Adap, Satanay Hubrack, and Khaled Machaca

TRPV5 and TRPV6 Calcium-Selective Channels

Ji-Bin Peng, Yoshiro Suzucki, Gergely Gyimesi, and Matthias A. Hediger

Determining the Crystal Structure of TRPV6

Kei Saotome, Appu K. Singh, and Alexander I. Sobolevsky

Identifying TRP Channel Subunit Stoichiometry Using Combined Single Molecule Single Channel Determinations (SC-SMD)

Laura G. Ceballos, Alexander Asanov, and Luis Vaca

Pharmacology of Store-Operated Calcium Entry Channels

Gary S. Bird and James W. Putney, Jr.