C-H Bond Activation in Organic Synthesis

Jie Jack Li

July 1, 2017 by CRC Press
Reference
ISBN 9781138894112 - CAT# K32864

USD$64.95

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Features

  • Highlights innovative applications of C–H functionalization of various substrates using palladium catalysis
  • Examines the use of nickel-catalyzed activation in natural product synthesis
  • Reviews selected literature reports of innovative C–H activation chemistry utilizing iron as a catalyst
  • Explores cobalt-catalyzed hydroarylation and C–H electrophile coupling since 2007
  • Covers recent and key developments, especially unusual reactivity

Summary

Greener than conventional methods, C–H activation methods have flourished during the last decade and become especially attractive to organic chemists. Edited by a practioner in this rapidly developing field, C–H Bond Activation in Organic Synthesis provides an overview of this exciting playground of chemistry. The book summarizes the state of the art in C–H activation for functionalization, enabling you to carry out reactions in the most environmentally friendly fashion with the least contamination of by-products.

The most popular C–H activation reactions are catalyzed by transition metals. This book dedicates a chapter to each of the following catalysts: palladium, rhodium, nickel, iron, copper, and cobalt. In addition, it covers radical-mediated C–H activation, fluorination via C–H activation, and C–H activation of heterocycles. Using a pedagogically practical approach, each chapter is divided by the transition metal catalyst, not a specific transformation. This gives you an up-to-date review of the most important topics of C–H activation.

The area of C–H activation has experienced a flurry of activity over the past two decades, so the time is right for a resource that summarizes these powerful tools with which you can design and construct heteroaromatic molecules. Thus, direct C–H functionalization methods are expected to continue to greatly contribute to the mission of green chemistry: low-energy, waste-free, and atom-economic transformations for the synthesis of organic materials and biologically active molecules in the twenty-first century. Using this book, you can carry out environmentally friendly reactions that enable the conversion of cheap and abundant alkanes into valuable functionalized organic compounds.

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