Summary
Addressing the dramatic number of children diagnosed with bronchopulmonary dysplasia (BPD) in recent years, Bronchopulmonary Dysplasia provides pulmonologists, critical care specialists, and pediatricians with up-to-date diagnostic and treatment techniques and therapies to effectively manage all BPD cases.
Key benefits include: groundbreaking research-covers the latest discoveries in BPD genetics, epidemiology, and pathogenesis, as well as current-and sometimes controversial-therapies to help clinicians properly detect the disease and choose the best treatment plan expert editorship-Dr. Steven H. Abman, Director of the Pediatric Heart Lung Center, and a team of 49 highly experienced and respected contributors provide authoritative advice physicians can rely on timely, stand-alone resource-this one-stop, convenient guide discusses all of the current, critical information clinicians need to manage the increase in diagnosed children well-organized content-four clear and highly structured sections give busy physicians quick access to the key diagnostic and therapeutic intricacies of BDP
Table of Contents
Part I: Mechanisms of Lung Growth and Development
Genetic Mechanisms of Lung Development and Bronchopulmonary Dysplasia: An Integrative View
David Warburton and Wei Shi
Growth Factors and Cell-Cell Interactions During Lung Development
Emily Fox and Martin Post
Basic Mechanisms of Alveolarization
Jacques R. Bourbon, Christophe Delacourt, and Olivier Boucherat
Lung Vascular Development
Alison A. Hislop
Part II: Mechanisms of Disrupted Lung Development and Repair in the Pathobiology of BPD
Oxidative and Nitrosative Stress and Bronchopulmonary Dysplasia
Richard L. Auten and Carl White
Prenatal Inflammation and Immune Responses of the Preterm Lung
Suhas Kallapur, Alan H. Jobe, and Boris W. Kramer
Inflammatory Mechanisms in Bronchopulmonary Dysplasia
Christian P. Speer
Disruption of Lung Vascular Development
William M. Maniscalco and Vineet Bhandari
Pulmonary Endothelial Progenitor Cells and Bronchopulmonary Dysplasia
Rebecca S. Rose, David A. Ingram, and Mervin C. Yoder
Effects of Mesenchymal Stem Cell Therapy in BPD
Bernard The´baud and Stella Kourembanas
Altered Growth Factor Signaling in the Pathogenesis of BPD
A. Keith Tanswell, Sanna Padela, and Robert P. Jankov
Part III: Clinical Aspects of BPD and its Management
Evolving Clinical Features of the New Bronchopulmonary Dysplasia
Eduardo Bancalari and Nelson Claure
Epidemiology of Bronchopulmonary Dysplasia
Linda J. Van Marter
Definitions of Bronchopulmonary Dysplasia and the Use of Benchmarking to Compare Outcomes
Michele C. Walsh
Genetics of Bronchopulmonary Dysplasia
Vineet Bhandari
Role of Management in the Delivery Room and Beyond in the Evolution of Bronchopulmonary Dysplasia
Maximo Vento and Ola Didrik Saugstad
Mechanical Ventilation: Early Strategies to Decrease BPD 314
Tina A. Leone and Neil N. Finer
Lung Function, Structure and the Physiologic Basis for Mechanical Ventilation of Infants with Established BPD
Robert G. Castile and Leif D. Nelin
Pulmonary Vascular Disease in Bronchopulmonary Dysplasia: Physiology, Diagnosis, and Treatment
Peter M. Mourani and Steven H. Abman
Drug Therapies in the Management of BPD
Henry L. Halliday
Lung Function Abnormalities in Infants and Children with Bronchopulmonary Dysplasia
Marco Filippone and Eugenio Baraldi
Long-Term Outcomes of Infants with BPD
Anne Greenough
Neurodevelopmental Outcomes of Children with Bronchopulmonary Dysplasia
Joy V. Browne
Part IV: Emerging Therapies in the Treatment of BPD
Inhaled Nitric Oxide in Premature Infants for the Prevention and Treatment of BPD
John P. Kinsella, Philip L. Ballard, Roberta A. Ballard, and Michael D. Schreiber
Vitamin A in the Prevention of Bronchopulmonary Dysplasia
Namasivayam Ambalavanan and Waldemar Carlo
The Use of Antioxidants to Prevent or Ameliorate Bronchopulmonary Dysplasia
Jonathan M. Davis and Richard Parad
Low-Dose Glucocorticoids for Prevention or Treatment of Bronchopulmonary Dysplasia
Kristi Watterberg
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