This incomparable Second Edition of a highly regarded reference has been entirely rewritten and enlarged to reflect the explosion of information and technologies that have emerged since the publication of the previous edition.
Strikes the perfect balance between proven traditional approaches and modern methods that promise to yield new products and processes!
Specifically addressing microbially derived commercially important bioactive products that are currently or soon-to-be available, Biotechnology of Antibiotics, Second Edition
analyzes the use of recombinant enzymes to produce biologically active molecules, including a cholesterol-lowering agent, an anti-HIV drug for the treatment of AIDS, and b-lactam antibiotics
gives insight into the biochemistry, molecular biology, and production of antibiotics used as therapeutic agents
focuses on state-of-the-art techniques for the development of new antibiotics using novel approaches and strategies
highlights recent advances in the genetic manipulation of antibiotic biosynthesis genes to create structures from gene combinations for new biological activities
describes in detail the development and current status of newly created antibiotics and pharmacologically active natural products
and much more!
Written by authorities from both industry and academia and containing nearly 4000 bibliographic citations, Biotechnology of Antibiotics, Second Edition is an outstanding resource for pharmaceutical scientists, medicinal chemists and biochemists, molecular biologists and industrial microbiologists, chemical engineers, fermentation bioengineers, bioprocess technologists, and upper-level undergraduate and graduate students in these disciplines.
Table of Contents
Introduction and Approaches for Improvement in Antibiotic Production
Template-Biosynthesized Peptide and b-Lactam Antibiotics
Ribosomally Synthesized Peptide Antibiotics
Polyketide Antibiotics Produced by Type-I Multifunctional Enzymes
Polyketide Antibiotics Produced by Type-II Polyketide Synthase Systems
Peptydil Nucleoside Antibiotics
Recombinant Bioconversions of Bioactive Molecules
Praise for the previous edition…
…a well-organized compilation of information on antibiotics which have found practical use in medical, veterinary, and agricultural practice…well written…a good reference work for those interested in antibiotic screening and production.
"…a very useful book…it is a great help to have in one book an account of the production of most of the current antibiotics.
"-Enzyme and Microbial Technology