1st Edition

Biology of Oral Cancer Key Apoptotic Regulators

    292 Pages 65 B/W Illustrations
    by CRC Press

    292 Pages 65 B/W Illustrations
    by CRC Press

    Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event—apoptosis—in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. 

    The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer.

    A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells’ normal state and be used to develop increasingly effective modalities.

    Cancer: A Worldwide Menace
    Epidemiology
    Diagnosis and Pathology
    Conclusion
    References

    Oral Cancer
    Key Words
    Introduction
    Epidemiology
    Signs and Symptoms
    Sex and Age Distribution
    Etiology
    Pathology
    Staging
    Individual Cancers of the Oral Cavity
    Conclusion
    References

    Proliferative and Apoptotic Signaling in Oral Cancer
    Key Words
    Introduction
    Regulation of Cell Homeostasis
    Somatic Gene Mutation
    Oncogenes and Tumor Suppressors
    NF-κB
    Serine/Threonine Kinases
    Steroid Hormones
    Central Role of Caspases
    Caspases Inhibitory Proteins
    Death Domains
    Fas/Fas Ligand
    TRAIL and Its Receptors
    Conclusion
    References

    Apoptotic Regulations
    Key Words
    Introduction
    Etymology
    Mechanisms of Apoptosis in Cancer
    Role of Apoptotic Regulators in Rheumatoid Arthritis (RA)
    Role of Apoptotic Regulators in Prostate Carcinoma
    Conclusion
    References

    Dynamics of p53 in Oral Cancer
    Key Words
    Introduction
    Functions and Roles in Causing Disease
    p53 as an Oncogene
    p53 as a Tumor Suppressor
    Mutations in p53
    Apoptotic Regulation by p53
    Interplay between Survivin and p53
    Clinicopathological Significance of p53
    Therapeutic Strategies Targeting p53
    Conclusion
    References

    Diagnostic and Therapeutic Potential of Apoptotic Marker
    Key Words
    Introduction
    Apoptotic Markers in Oral Cancer Therapeutics
    Apoptotic Markers in Oral Cancer Diagnostics
    Conclusion
    References

    Expression and Regulation of Survivin
    Key Words
    Introduction
    Molecular Organization and Structure of Survivin
    Functions of Survivin
    Regulation of Survivin
    Anti-Apoptotic Network of Survivin
    Expression of Survivin in Normal Tissues
    Expression of Survivin in Human Cancer
    Conclusion
    References

    Therapeutics of Survivin
    Key Words
    Introduction
    Manipulation of the Survivin Gene
    Factors Inducing Survivin Expression
    Downregulation of Survivin
    Ribozyme-Mediated Degradation of Survivin
    Immunotherapy
    Therapeutic Biology of Survivin
    Survivin-Directed Cancer Therapy
    Regulation of Survivin in Head and Neck Squamous Carcinoma
    Prognostic and Diagnostic Significance of Survivin
    Therapeutic Approach
    Survivin for Cancer Immunotherapy
    Conclusion
    References

    Molecular Diagnosis of Oral Cancer
    Key Words
    Introduction
    Molecular Markers for Oral Cancer
    Molecular Mechanism of Development of Oral Cancer
    The Hallmarks of Oral Cancer
    Other Markers
    Diagnosis of Oral Squamous Cell Carcinoma
    Conclusion
    References
    Glossary
    Index

    Biography

    Prakash S. Bisen, Zakir Khan, Saurabh Bundela