Biology of Antithrombins

Geza Sas

November 30, 1989 by CRC Press
Reference - 192 Pages
ISBN 9780849347771 - CAT# 4777


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  • Antithrombin III
  • "Heparin cofactor" and "heparin cofactor II"
  • d2-Macroglobulin, d2-Antitrypsin as thrombin inhibitors
  • Inherited and acquired antithrombin deficiencies
  • Effective and safe therapy.
  • Summary

    This publication covers topics related to the biochemistry and clinical significance of the proteins displaying thrombin-inhibiting activity. Only in the past twenty-five years has the biological significance of proteins inhibiting blood coagulation been recognized. These inhibitors play a key role in the regulation of blood coagulation by controlling the activated serine proteinases. Certain proteins, the antithrombins, exert their effect upon thrombin leading to a reduction in the rate of fibrin formation. Important work has been done with thrombosis; chronic liver disease; disseminated intravascular coagulation; thromboembolic episodes during pregnancy, delivery; and oral contraceptive therapy. Substitution of purified, concentrated antithrombin III fractions has proven to be an effective and safe therapy for patients with antithrombin-III deficiencies.
    This important addition to scientific literature is of value to those of hematology, thrombosis research, transfusion technology and biochemistry.