Biocalorimetry: Foundations and Contemporary Approaches

1st Edition

Margarida Bastos

CRC Press
Published May 9, 2016
Reference - 416 Pages - 115 B/W Illustrations
ISBN 9781482246650 - CAT# K23600

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Features

  • Presents contributions from world-renowned scientists who developed the main instruments used in the field
  • Discusses the historical and methodological background of biocalorimetry
  • Covers both thermodynamics and kinetics, including new approaches on kinetics derived from isothermal titration calorimetry (ITC) for proteins and membrane partition
  • Describes new ways to deal with data from proteins, DNA, and membranes as well as interpret the obtained results
  • Includes various applications that illustrate the use of calorimetry to monitor bacterial populations and biofilms, study enzyme catalysis, investigate clinical samples, and aid in pharmaceutical drug development

Summary

Connecting past, present, and future instrument development and use, Biocalorimetry: Foundations and Contemporary Approaches explores biocalorimetry’s history, fundamentals, methodologies, and applications. Some of the most prominent calorimeter developers and users share invaluable personal accounts of discovery, discussing innovative techniques as well as special and original applications. Wide in scope, the book also covers calorimetry use on membranes, nucleic acids, and proteins and addresses both thermodynamics and kinetics.

The book begins with a look at the historical development of calorimeters needed for biological research. It then describes advanced approaches that use high-quality commercial calorimeters to study biochemical and other biological processes. It also shows how novel experimental designs and data analysis procedures are applied to proteins, DNA, membranes, and living matter.

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