Provides an overview of modern methodology in the search for bioactive compounds from natural sources Explores research on bioactive natural products with emphasis on the biological properties of the compounds citedIncludes extensive coverage of marine metabolites, their applications in the pharmaceutical industry, and their role in understanding the chemical ecology of marine habitatsEncourages a disciplinary approach to the study of bioactive secondary metabolites among pharmacologists, biologists, botanists, agronomists
Interest in obtaining biologically active compounds from natural sources has recently spiked due to their low toxicity, complete biodegradability, availability from renewable sources, and in most cases, low cost. Taking an interdisciplinary approach, Bioactive Compounds from Natural Sources: Isolation, Characterization, and Biological Properties covers general methods and main topics in the research field of bioactive natural products.
The book describes general screening methods, modern HPLC hyphenated techniques, and NMR methods in the structural elucidation of compounds and devotes individual chapters to specific topics of research. Surveys on compounds displaying important pharmacological activities are presented in chapters devoted to Mexican medicinal plants, anti-tumor drugs of natural origin, cancer chemopreventive flavonoids, and metabolites displaying anti-HIV, antioxidative, antimalarial, and anti-inflammatory activity. The final chapters are devoted to representative examples of research into marine metabolites: immunomodulating marine glycolipids and surveys of bioactive compounds from marine opisthobranchs and Japanese soft corals.
With its focus on modern approaches to the isolation of biologically active natural products, this book encourages interdisciplinary work among chemists, pharmacologists, biologists, botanists, and agronomists with an interest in bioactive natural products.
Table of Contents
Biological Screening Methods in the Search for Pharmacologically Active Natural Products; A.J. Vlietinck and S. Apers
Applications of Liquid Chromatography/UV/MS and Liquid Chromatography/NMR for the On-line Identification of Plant Metabolites; K. Hostettmann and J.L. Wolfender
Applications of Modern NMR Techniques in the Structural Elucidation of Bioactive Natural Products; P. Neri and C. Tringali
Bioactive Secondary Metabolites From Selected Mexican Medicinal Plants: Recent Progress; R. Mata, J.F. Rivero-Cruz and D. Chávez
Flavonoids as Cancer Chemopreventive Agents; L.C. Chang and A.D. Kinghorn
Anti-tumor Drugs from the Secondary Metabolites of Higher Plants; Y.H. Kuo and M.L. King
Bioactive Taxoid Production from Natural Sources; M. Jaziri and M. Vanhaelen
Anti-HIV Aromatic Compounds from Higher Plants; F. De Simone, R. Aquino, N. De Tommasi, N. Mahmood, S. Piacente and C. Pizza
Antioxidative Plant Constituents; H. Haraguchi
Antimalarial Natural Products; S. Brøgger Christensen and A. Kharazmi
Search for Natural Products with Effect on Cyclooxygenase-2; P. Perera, T. Ringbom, U. Huss, M. Vasänge and L Bohlin
Phytotoxins From Fungi Pathogenic for Agrarian, Forestall and Weedy Plants; A. Evidente and A. Motta
Limonoids From Meliaceae and their Biological Activities; M. Nakatani
Glycolipids with Immunomodulating Activity From Marine Sponges; V. Constantino, E. Fattorusso and A. Mangoni
Metabolites of Marine Opistobranchs: Chemistry and Biological Activity; G. Cimino, M.L. Ciavatta, A. Fontana and M. Gavagnin
Bioactive Diterpenoids From Japanese Soft Corals; K. Yamada and R.. Higuchi