Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning of bio-implant interface reactions will have a tremendous impact on future design and prospects of implant treatments.
Bio-Implant Interface: Improving Biomaterials and Tissue Reactions brings together a remarkable panel of scientists to present the state-of-the-art in our understanding of interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface's topography and chemistry to its interaction with the biological environment. Biomineralization along with the biological content of the interface and its role in directing cellular response along desired pathways also receive particular attention.
The pursuit of new and better designs for improved biocompatibility and patient response to implants continues to challenge clinicians and scientists alike. This book offers a unique opportunity to bring yourself up-to-date on recent advances in the field and new strategies for controlling the bio-implant interface.
Table of Contents
SUCCESS AND FAILURE FOR BONE-IMPLANT ATTACHMENTS: AN EVIDENCE-BASED APPROACH
The Role of Implant Surface Properties on the Clinical Outcome of Osseointegrated Oral Implant Therapy, M. Esposito, H.V. Worhington, P. Coulthard, A. Wennerberg, P. Thomsen
CAN THE IMPLANT MACRO DESIGN AND MICRO TEXTURING IMPROVE BONE RESPONSE?
Toward an Optimized Dental Implant Design, S. Hansson
Implant Surface Design for Development and Maintenance of Osseointegration, R. Pilliar
Bone Response to Surface Roughness; Measurement and Results, Experiment and Clinical Studies, A. Wennerberg, T. Albrektsson
From Microroughness to Resorbable Bioactive Coatings, S. Szmukler-Moncler, P. Zeggel, D. Perrin, J-P Bernard, H-G Neumann
CELL AND TISSUE REACTIONS TO BIOMATERIALS Improving the Bio-Implant Interface by Controlling Cell Behavior Using Surface Topography, D. Brunette, A. Khakbaznejad, M. Takekawa, M. Shimonishi, H. Murakami, M. Wieland, B. Chehroudi, J. Glass-Brudzinski, M. Textor
Osteoblast Response to Pure Titanium and Titanium Alloy, M. Paine, J.C. Wong
Biomedical Implant Surface Topography and its Effects on Osteoblast Differentiation in vitro, C. Stanford, G. Schneider, H. Perinpanayagam, J.C. Keller, R. Midura
Cellular Interactions at Commercially Pure Titanium Implants, L.F. Cooper
A Selection of Oral Implant Materials Based on Experimental Studies, P. Thomsen, C.B. Johansson
Possibilities to Improving Implants and Regenerating Dentoalveolar Tissues by Tissue Engineering Using Stem Cells and Growth Factors, I. Thesleff, M. Tummers
Critical Issues in Endosseous Peri-Implant Wound Healing, J.E. Davies, J.Y. Park
THE EXTRACELLULAR MATRIX BIOLOGY AND BIOMINERALIZATION IN BONE FORMATION AND IMPLANT INTEGRATION
Initiation and Modulation of Crystal Growth in the Skeletal Tissues: Role of the Extracellular Matrix, C. Robinson, R.C. Shore, S.R. Wood, S.J. Brookes, D. Alistair Smith, J. Kirkham
Use of a Matrix Scaffold for Tissue Engineering and Bone Regeneration, M. Bartold, Y. Xiao
Inducing Bone Growth Using Extracellular Matrix Proteins, S.P. Lyngstadaas, J.E. Ellingsen, A. Spahr, I. Slaby
SURFACE CHEMISTRY, BIOCHEMISTRY, AND MOLECULES: HOW DO THEY INTERACT WITH BIOLOGICAL ENVIRONMENT?
How Surfaces Interact with the Biological Environment, P. Tengvall
Osteocapacities of Calcium Phosphate Ceramics, J. Jansen, P.J. Rugge, E. van der Wal, A.M. Vredenberg, J.G.C. Wolke
Increasing Biocompatibility by Chemical Modification of Titanium Surfaces, J.E. Ellingsen, S.P. Lyngstadaas
Use of Molecular Assembly Techniques for Tailoring Chemical Properties of Smooth and Rough Titanium Surfaces, M. Textor, S. Tosatti, M Wieland, D.M. Brunette
DEVELOPMENT AND APPLICATION OF SCIENTIFIC DATA: REGULATORY AND COMMERCIAL ASPECTS
Development and Application of Scientific Data: Do Industry and Academia Have Different Scientific Perspectives? B. Delin
Medical Devices--Regulatory Perspectives and Aspects of Regulatory Risk Management, S. Gestrelius, A. Hensten-Pettersen
INVENTIVE FORWARD LOOKS-WHERE DO WE GO FROM HERE?
Self-Assembling and Bimimetic Biomaterials, S. Stupp, E. Beniash, J.D. Hartgerink, E.D. Sone
The Inert-Bioactivity Conundrum, D.F. Williams
Enhancing the Process of Discovery and Innovation for Optimal Host Response at the Implant Surfaces, M.L. Snead