Big Data in Omics and Imaging: Integrated Analysis and Causal Inference

Momiao Xiong

© 2018 - Chapman and Hall/CRC
Published June 19, 2018
Reference - 736 Pages - 40 B/W Illustrations
ISBN 9780815387107 - CAT# K345128
Series: Chapman & Hall/CRC Mathematical and Computational Biology

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  • Bridges the gap between the traditional statistical methods and computational tools for small genetic and epigenetic data analysis and the modern advanced statistical methods for big data
  • Provides tools for high dimensional data reduction
  • Discusses searching algorithms for model and variable selection including randomization algorithms and matrix subset selection
  • Provides real-world examples and case studies
  • Will have an accompanying website with R and possibly C code


Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.



  • Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently.
  • Introduce causal inference theory to genomic, epigenomic and imaging data analysis
  • Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies.
  • Bridge the gap between the traditional association analysis and modern causation analysis
  • Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks
  • Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease
  • Develop causal machine learning methods integrating causal inference and machine learning
  • Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks


The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.


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