Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Table of Contents
Pharmacology of Endotoxins: Cyclic Nucleotides and Lipopolysaccharide Action (R.G. Coffey and J.W. Hadden). Endotoxin-Induced Oxidative Metabolism of Unsaturated Fatty Acids (F.U. Schade, R. Engel, D. Jakobs, and T. Kirikae). Interactions between Platelet-Activating Factor and Lipopolysaccharide: Consequences in Endotoxemia and Sepsis (D. Hosford and P. Braquet). Tumor Necrosis Factor and Host Response to Endotoxin (C. Galanos, M.A. Freudenberg, T. Katschinski, R. Salomao, H. Mossmann, and Y. Kumazawa). Role of Interleukin 1 in Systemic Responses to LPS (C.A. Dinarello). Interleukin 6 and LPS Host Response (R.E. McCallum and M.R. Hill). Lipopolysaccharide-Induced Interferon (S.N. Vogel). Novel Lipopolysaccharide-Induced Cytokines (S.J.H. van Deventer and A. Cerami). Interactions of LPS with Serum Complement (S.W. Vukajlovich). Immunopathophysiology of Endotoxins: Studies of the Natural History and Mechanism of the Primate (Baboon) Response to Escherichia Coli (F.B. Taylor, Jr.). Metabolism of LPS In Vivo (M.A. Freudenberg and C. Galanos). The Endocrine Response to Endotoxin (R. Silverstein). Endotoxin and Cytokine Responses in Human Volunteers (J.G. Cannon). Endotoxin and Meningococcemia: Intravascular Inflammation Induced by Native Endotoxin in Man (P. Brandtzaeg and P. Kierulf). Specificity and Function of Lipopolysaccharide Antibodies (M. Pollack). The Protective Role of Antibodies to the Lipopolysaccharide Core Region (B.J. Appelmelk and J. Cohen). Monophosphoryl Lipid A and Immunotherapy (K.B. Von Eschen). Lipid A and Liposomes Containing Lipid A as Adjuvants for Vaccines (C.R. Alving). Index.