Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery

Graca Soveral, Soren Nielsen, Angela Casini

November 1, 2017 by CRC Press
Reference - 356 Pages - 16 Color & 47 B/W Illustrations
ISBN 9781138894013 - CAT# K32856


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  • Provides state-of-the-art overviews of the structure, function, and physiological roles of aquaporins in health and diseases
  • Shows how aquaporins are interesting molecular targets for drug discovery
  • Covers the structure-function relationship and analytical methods for assessing aquaporin function
  • Examines physiological mechanisms of regulation in health and disease as well as chemical inhibition by small-molecule compounds that may present drug development opportunities
  • Explores future challenges and possibilities in aquaporin pharmacology


Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties.

Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book’s epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics.

Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.


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