Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiato
Table of Contents
1. Apoptosis: Basic Mechanisms and Relevance to Toxicology J.H. Gill and C. Dive 2. The Toxicological Consequences of Caspase Inhibition and Activation K. Cain 3. Modulation of Apoptosis in Immunotoxicology J. Schumann and G. Tiegs 4. Apoptosis in Male Reproductive Toxicology I. Woolveridge and I.D. Morris 5. Apoptosis in Female Reproductive Toxicology J. Tilly 6. Apoptosis in Renal Toxicology M. Davis 7. Role of Apoptosis in Neuronal Toxicology R.M. Gibson 8. Perurbation of Apoptosis as a Mechanism of Action of Nongenotoxic Carcinogens S.C. Cosulich and R.A. Roberts 9. Toxic Mechanisms Mediated by Gene Expression P.R. Holden 10. Detection and Biomarkers of Apoptosis J.R. Foster K. Cain, University of Leicester, UK, J. Schumann and G. Tiegs, Freidrich Alexander Universt Erlangen-N rnberg, Germany, I. Woolveridge, Roche Discovery, UK. I.D Morris, University of Manchester, UK, J. Tilly, Harvard Medical School, USA, M. Davis, University of Maryland, USA, R.M. Gibson, University of Manchester, UK, S.C. Cosulich, AstraZeneca, UK, R.A. Roberts, AstraZeneca, UK, P.R. Holden, AstraZeneca, UK, J.R. Foster, AstraZeneca, UK.