Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiator and executioner caspases.
Emphasis is given to the role apoptosis plays in the action of toxicants in the brain, the immune system, the reproductive organs, the kidney and the liver. The ability of drugs to regulate apoptosis either as a target or as an adverse effect is discussed with particular reference to cancer chemotherapy. The many methods that can be employed to quantify apoptosis are compared and their application to different tissues is discussed.
This timely and comprehensive volume has been written by leading authorities and active researchers in their respective fields. It will have broad appeal to toxicologists, physicians and biologists across many disciplines.
Table of Contents
1. Apoptosis: Basic Mechanisms and Relevance to Toxicology J.H. Gill and C. Dive 2. The Toxicological Consequences of Caspase Inhibition and Activation K. Cain 3. Modulation of Apoptosis in Immunotoxicology J. Schumann and G. Tiegs 4. Apoptosis in Male Reproductive Toxicology I. Woolveridge and I.D. Morris 5. Apoptosis in Female Reproductive Toxicology J. Tilly 6. Apoptosis in Renal Toxicology M. Davis 7. Role of Apoptosis in Neuronal Toxicology R.M. Gibson 8. Perurbation of Apoptosis as a Mechanism of Action of Nongenotoxic Carcinogens S.C. Cosulich and R.A. Roberts 9. Toxic Mechanisms Mediated by Gene Expression P.R. Holden 10. Detection and Biomarkers of Apoptosis J.R. Foster K. Cain, University of Leicester, UK, J. Schumann and G. Tiegs, Freidrich Alexander Universtät Erlangen-Nürnberg, Germany, I. Woolveridge, Roche Discovery, UK. I.D Morris, University of Manchester, UK, J. Tilly, Harvard Medical School, USA, M. Davis, University of Maryland, USA, R.M. Gibson, University of Manchester, UK, S.C. Cosulich, AstraZeneca, UK, R.A. Roberts, AstraZeneca, UK, P.R. Holden, AstraZeneca, UK, J.R. Foster, AstraZeneca, UK.