This volume summarizes current understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complications, and presents results of studies aimed at regulating oxidatively induced complications through the use of antioxidants.
Examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications!
Designed to stimulate scientific discussion and curiosity about the causes of diabetes, with contributions from nearly 65 clinicians and researchers who cite more than 1300 sources, Antioxidants in Diabetes Management
focuses on stringent control of hyperglycemia to prevent or modify onset and progression
promotes the development of intervention strategies because of the therapeutic limitations of hypoglycemic therapy
emphasizes the potential synergistic effects of an interlinked antioxidant network
investigates the controversy surrounding the significance of oxidative stress markers in diabetes
highlights oxidative stress and antioxidant treatment in animal models for juvenile and adult onset diabetes
explores the hypothesis that ischemic reperfusion is the primary cause of diabetic polyneuropathy
links protein kinase C activation to the development of diabetic vascular complications and the effectiveness of vitamin E in preventing these abnormalities
spotlights recent clinical trials of therapeutic effects of antioxidants to reduce insulin resistance
and much more!
Illustrating the therapeutic potential of antioxidants for the treatment of diabetes, Antioxidants in Diabetes Management is an unparalleled reference for endocrinologists, nutritionists and dietitians, cell biologists and biochemists, cardiologists, pathologists, and graduate and medical school students in these disciplines.
Table of Contents
Oxidative Stress and Antioxidants: The Antioxidant Network, -Lipoic Acid, and Diabetes
Oxidative Stress in Diabetes: Why Does Hyperglycemia Induce the Formation of Reactive Oxygen Species?
Peter Rösen, Xue Liang Du, and Guang-Zhi Sui
Oxidative Stress Markers in Human Disease: Application to Diabetes and to Evaluation of the Effects of Antioxidants
Plasma Lipid Hydroperoxide and Vitamin E Profiles in Patients with Diabetes Mellitus
Concentrations of Antioxidative Vitamins in Plasma and LDL of Diabetic Patients
Oxidative Stress in Diabetes
John W. Baynes and Suzanne R. Thorpe
Antioxidative Defense in Diabetic Peripheral Nerve: Effects of DL- -Lipoic Acid, Aldose Reductase Inhibitor and Sorbitol Dehydrogenase Inhibitor
Irina G. Obrosova, Douglas A. Greene, and Hans-Jochen Lang
Pathways of Glucose-Mediated Oxidative Stress in Diabetic Neuropathy
Douglas A. Greene, Irina G. Obrosova, Martin J. Stevens, and Eva L. Feldman
Experimental Diabetic Neuropathy: Oxidative Stress and Antioxidant Therapy
Hans J. Tritschler, James D. Schmelzer, Yutaka Kishi, Yoshiyuki Mitsui, Masaaki Nagamatsu, Kim K. Nickander, Paula J. Zollman, and Phillip A. Low
Antioxidants in the Treatment of Diabetic Polyneuropathy: Synergy with Essential Fatty Acids
Norman E. Cameron and Mary A. Cotter
A Thioctic Acid-Gamma-Linolenic Acid Conjugate Protects Neurotrophic Support in Experimental Diabetic Neuropathy
Luke Hounsom and David R. Tomlinson
Clinical Trials of -Lipoic Acid in Diabetic Polyneuropathy and Cardiac Autonomic Neuropathy
Oxidative Stress, NF-kB Activation, and Late Diabetic Complications
Peter P. Nawroth, Valentin Borcea, Angelika Bierhaus, Martina Joswig, Stephan Schiekofer, and Hans J. Tritschler
Molecular Basis of -Tocopherol Action and Its Protective Role Against Diabetic Complications
Angelo Azzi, Roberta Ricciarelli, Sophie Clément, and Nesrin Özer
Protein Kinase C Activation, the Development of Diabetic Vascular Complications, and the Role of Vitamin E in Preventing These Abnormalities
Sven-Erik Bursell and George L. King
Oxidative Stress and Pancreatic -Cell Destruction in Insulin-Dependent Diabetes Mellitus
Mizuo Hotta, Eiji Yamato, and Jun-ichi Miyazaki
Interrelationship Between Oxidative Stress and Insulin Resistance
Karen Yaworsky, Romel Somwar, and Amira Klip
Oxidative Stress and Antixodant Treatment: Effects on Muscle Glucose Transport in Animal Models of Type 1 and Type 2 Diabetes
Erik J. Henriksen
Oxidative Stress and Insulin Action: A Role for Antioxidants?
Stephan Jacob, Rainer Lehmann, Kristian Rett, and Hans Ulrich-Häring
...an excellent book.
The Nutrition Reporter
...serves as a valuable reference for the state-of-the-art research being conducted in this field.
"- American Journal of Pharmaceutical Education, 2000
...this book is...unique in providing an overview of the role of oxygen free radicals in diabetes; the authors should be commended for an admirable job in framing a succinct review of the pathophysiology associated with the development of diabetes and its associated complications, and opportunities that antioxidants might offer for therapy in diabetes.
-Trends in Endocrinology & Metabolism, 2001