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Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them, their properties and structural characteristics is still incomplete. The Antibodies: Volume 2 is a comprehensive review of topics of contemporary interest for specialists in B cell immunology. This volume investigates such topics as sequencing the variable regions of human antibodies directed against exogenous antigens; a review of the protective immune response; a review of the utilization of the VH4-34 (VH4-21) gene segment in normal, neoplastic and autoimmune repertoires; and a review of antigenized antibodies. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Table of Contents
1. Variable Region Gene Utilization in Human Antibodies to Exogenous Antigens 2. VH4-34 (VH4-21) Immunoglobulin Gene Expression in Normal, Neoplastic, and Autoimmune Repertoires 3. Antigenized Antibodies from Concept to Applications 4. The Development and Evolution of the Human Antibody Repertoire 5. Structure-Function Relation in Natural and Disease-Associated Human Antibodies 6. The Structural Basis of Human Idiotypes
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CHOICE – Outstanding Academic Title – Award Winner
CHOICE – 2018 Outstanding Academic Title – Award Winner
Shingo Research and Professional Publication Award Winner
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