Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding.
This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.
Introduction
Shayne Cox Gad
The Mouse
Shayne Cox Gad, Charlie Clifford, and Dawn Goodman
The Rat
Mark D. Johnson, Shayne Cox Gad, and Christopher J. Kemper
The Hamster
Shayne Cox Gad and Frederick G. Hess
The Guinea Pig
Shayne Cox Gad and John Peckham (deceased)
Rabbit
Clare M. Salamon and Shayne Cox Gad
The Ferret
Daniel E. McLain and Shayne Cox Gad
The Dog
Shayne Cox Gad, Mark Morse, and Christopher J. Kemper
Primates
Mark D. Walker, Michael V. Templin, John C. Bernal, Stewart B. Jacobson, and Shayne Cox Gad
The Minipig
Shayne Cox Gad and Alain Stricker-Krongrad
Alternative Species
Shayne Cox Gad
Clinical Pathology of Laboratory Animals
Niraj K. Tripathi and Robert L. Hall
Telemetry in Nonclinical Drug Safety Assessment Studies
R. Dustan (Dusty) Sarazan
Molecular Imaging Techniques in Laboratory Animals
Zheng J. Wang, Ting-Tung A. Chang, Richard Slauter, Stephen R. Porter, Avinash Srivatsan, and Xiaoyuan Chen
Genetically Modified Animal Models
JoAnn Schuh
Model Selection and Scaling (Allometry)
Shayne Cox Gad
Susceptibility Factors
Shayne Cox Gad
Laws, Regulations, and Guidelines for Animal Care and Use in Research
Charles B. Spainhour and Laurie M. Serfilippi
Necropsy and Gross Pathology
Charles B. Spainhour
Biography
Edited by
Shayne Cox Gad, PhD, DABT, is the principal of Gad Consulting Services in Raleigh, North Carolina. He has more than 38 years of broad-based experience in toxicology, drug, device development, document preparation, statistics, and risk assessment, having previously been the director of toxicology and pharmacology for Synergen, director of medical affairs technical support system services for Becton Dickinson, and senior director of product safety and pharmacokinetics for G.D. Searle. He is past president of the American College of Toxicology and Roundtable of Toxicology Consultants and a board-certified toxicologist. Dr. Gad has published 47 books and more than 350 chapters, papers, and abstracts.
"…should be in every toxicology laboratory that performs research involving animals. No other book … provides the same breadth and depth of information as found here…"
—Michele T. Pritchard, PhD, University of Kansas Medical Center in Doody’s Book Reviews
