1st Edition
Animal Models in Orthopaedic Research
Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic conditions and in the in vivo study of biomaterials. Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. Directed primarily toward surgeons, investigators, research fellows, graduate students, and those working in orthopaedic or biomaterial research, this book is intended to serve as a basis for a literature search before embarking on a detailed research project.
This book is the result of the editors' own quest for information about research methodology and the use of animal models in orthopaedic and biomaterial research. Concise, inclusive, and practical, this work:
Ethics and Regulations for the Care and Use of Laboratory Animals, A.C. Smith, R.T. Fosse, and M.M. Swindle
Experimental Design, Evaluation Methods, Data Analysis, Publications, and Research Ethics, Y.H. An and T.D. Bell
Animal Selections in Orthopaedic Research, Y.H. An and R. Friedman
Surgical Facilities, Peri-Operative Care, Anesthesia, and Surgical Techniques, A.C. Smith and M.M. Swindle
Euthanasia and Necropsy, S.A. Bingel
Evaluation Methods in Orthopaedic Animal Research
Methods of Evaluation in Orthopaedic Animal Research, Y.A. An
Histological Study in Orthopaedic Animal Research, H.E. Gruber and A.A. Stasky
Mechanical Properties and Testing Methods of Bone, Y.H. An and R.A. Draughn
Mechanical Testing of Cartilage, M. LaBerge
Mechanical Testing of Ligament and Tendon, S. L-Y. Woo, T.T. Manson, and T.M. Vogrin
Animal Models of Bone Conditions
Animal Models of Fracture or Osteotomy, Y.H. An, R.J. Freidman, and R.A. Draughn
Animal Models for Testing Bioabsorbable Materials, Y.A. An and R.J. Friedman
Animal Models of Bone Defect Repair, Y.A. An and R.J. Friedman
Animal Models of Osteonecrosis, K. Masuhara, M. Matui, K. Nakata, and K. Ono
Animal Models of Osteopenia or Osteoporosis, D. B. Kimmel, E.L. Moran, and E.R. Bogoch
Animal Models of Articular Cartilage Defect, Y.H. An and R.J. Friedman
Animal Models of Meniscal Repair, J. Klompmaker and R.P.H. Veth
Animal Models of Osteoarthritis, T.R. Oegema, Jr. and D.M. Visco
Animal Models of Inflammatory Arthritis, E.L. Moran and E.R. Bogoch
Animal Models of Joint Replacement and Related Conditions
Animal Models for Studying Soft Tissue Biocompatibility of Biomaterials, J.A. Jansen
Animal Models for Studying Bone Ingrowth and Joint Replacement, D.R. Sumner, T.M. Turner, and R.M. Urban
Animal Models for Investigations of Biomaterial Debris, M.Lind, Y. Song, and S.B. Goodman
Animal Models of Prosthetic Infection, Y.H. An and R.J. Friedman
Animal Models for the Study of Ligaments and Tendons
Animal Models of Ligament Repair, J.J. McDougall and R.C. Bray
Animal Models of Tendon Repair, D.L. Pruitt
Animal Models for Ligament and Tendon Fixation to Bone, F.A. Young and Y.H. An
Animal Models of Spinal Conditions
Animal Models of Spinal Instability and Spinal Fusion, H.S. Sandhu, L.E.A. Kanim, F. Girardi, F.P. Cammisa, Jr., and E. D. Dawson
Animal Models of Spinal Cord Compression, S. Miyamoto, K. Yonenobu, and K. Ono
Animal Models of Transplantation and Replacement of Vertebral Column and Intervertebral Disc, H. Matsuzaki and K. Wakabayashi
Animal Models of Scoliosis, N. Kawakami, M. Deguchi, and T. Kanemura
Microsurgical Technique in Orthopaedic Animal Models, Y.H. An
Appendix
Abbreviations
Journals and Publications Related to Orthopedic Research and Laboratory Animals
Major Sources of Laboratory Animals
Index
Biography
Yuchuei H. An, M.D. is Associate Professor and Co-director of the Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston, SC, and Adjunct Assistant Professor of Bioengineering, Department of Bioengineering, Clemson University, Clemson, Sc. Dr. An graduated from the Harbin Medical University, Harbin, China, in 1983 and was trained in orthopaedic surgery at ii Shui Tan Hospital (residency), Beijing, China, and in hand surgery at Sydney Hospital (Clinical Fellow), Sydney, Australia. In 1991, Dr. An joined with Dr. Richard J. Friedman in the Department of Orthopaedic Surgery at the Medical University of South Carolina to establish an Orthopaedic Research Laboratory. Since then, he has been directing and supervising graduate students, research fellows, and residents on numerous orthopaedic research projects, Dr. An has published more than 50 scientific papers and book chapters and presented more than 60 research abstracts. He is an active member of six academic societies, including the Orthopaedic Research Society (USA), Society for Biomaterials (USA), American Society of Biomechanics, and Tissue Engineering Society (USA). Dr. An’s current research interests include repair of bone and cartilage defects using tissue engineering techniques, improving bone or soft tissue ingrowth to implant surfaces, prevention of bacterial adhesion and prosthetic infection, and development of animal models for orthopacdic applications. He enjoys art and created most of the drawings used in his chapters. Richard J. Friedman, M.D., FRCS(C), is Professor and Director of the Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston, SC, and Adjunct Professor of Bioengineering. Department of Bioengineering, Clemson University, Clemson, SC. He graduated from the University of Toronto School of Medicine in 1980 and after that was trained in orthopaedic surgery at Johns Hopkins University and Harvard University. Dr. Friedman is the founder and director of the Orthopaedic Research Laboratory at the Medical University of South Carolina. He has published more than 100 scientific papers and book chapters and presented more than 200 research abstracts. In 1994. he edited Arthroplasry of the Shoulder published by Thiemc Medical Publishers, New York, a reference book in human shoulder arthroplasty. He has been invited as a guest speaker for many national and international academic meetings. He has served as a chairman or member of more than 30 academic or professional committees or meetings and is a member of more than twenty societies or associations. Dr. Friedman’s current research interests include shoulder and elbow surgery, bone and cartilage repair using tissue engineering techniques, bone ingrowth, total joint replacement, orthopaedic biornaterials, and development of animal models for orthopaedic applications.
