This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
Table of Contents
Introduction: Angiotensin II Receptors, D.P. Brooks and R.R. Ruffolo, Jr.
Angiotensin II Receptor Subclassification, R.M. Edwards and R.R. Ruffolo, Jr.
Molecular Biology of Angiotensin II Receptors, D.J. Bergsma
Angiotensin II Receptor Signal Transduction Mechanisms, R.M. Edwards and R.R. Ruffolo, Jr.
Functions Mediated by Peripheral Angiotensin II Receptors, D.P. Brooks and R.R. Ruffolo, Jr.
Functions Mediated by Angiotensin II Receptors in the Brain, D.P. Brooks and R.R. Ruffolo, Jr.
Therapeutic Applications of Angiotensin II Antagonists, M.I. Freed, B.E. Ilson, N.H. Shusterman, and D.K. Jorkasky