This text is a source of information on the toxicity of anaesthetic agents. The editors define toxicity in a broad sense to mean an adverse effect, whether that effect is the result of pharmacological, toxicological, physiological, or other mechanisms. They bring together reviews by experts in the disciplines concerned - including biochemistry, genetics, and immunology - involved in current research on these adverse effects.; The initial chapters provide an understanding of the factors responsible for toxicity, and the ways in which the adverse effects of anaesthetics can be investigated. Subsequent chapters cover topics such as: hepatotoxicity; nephrotoxicity; malignant hyperthermia triggered by anaesthetics; pulmonary effects of anaesthesia; toxicity of local anaesthetic agents; toxicity of nitrous oxide; immunosuppression in the postoperative period; and reproductive and developmental toxicity of anaesthetics. Many of the contributors offer insights into the anaesthetics and their interactions, such as the immunological effects of anaesthesia and the impact of pharmacogenetics.
Table of Contents
Anaesthetic Toxicity: An Overview, Susan A. Rice and Kevin J. Fish Animal Use in Toxicity Evaluation , Victor S. Lukas, Jr. Principles of Epidemiology for Evaluation of Anaesthetic Toxicity, Kristie L. Ebi Metabolism of the Volatile Anaesthetics, Lucy Waskell Hepatotoxicity of Halogenated Anaesthetics, Max T. Baker and Russell van Dyke Nephrotoxicity of Volatile Anaesthetic Agents, Kevin J. Fish The Toxicity of Local Anaesthetic Agents, Hal S. Feldman Toxicity of Nitrous Oxide, Donald D. Koblin Reproductive and Developmental Toxicity of Anaesthetics in Animals, Susan A. Rice Reproductive and Developmental Toxicity of Anaesthetics in Humans, Kristie L. Ebie and Susan A. Rice Pharmacogenetics and Anaesthetic Toxicity, Margaret Wood Malignant Hyperthermia Triggered by Anaesthetics, Marilyn Green Larach Immunosuppression in the Postoperative Period, Girish C. Moudgil Pulmonary Effects of Anaesthesia, Brian P. Kavanagh and Ronald G. Pearl Biomarkers of Anaesthetic Toxicity, C. Murray Ardie.