1st Edition

Amyotrophic Lateral Sclerosis Advances and Perspectives of Neuronanomedicine

By Lina Machtoub, Yu Kasugai Copyright 2016
    158 Pages 4 Color & 37 B/W Illustrations
    by Jenny Stanford Publishing

    Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative, highly sensitive, and novel diagnostic molecular imaging approaches. In addition, the book offers new perspectives of an innovative and recently developed approach in neuroimaging using surface-enhanced nanoimaging microscopy, which can be a promising technique for early diagnosis and treatment assessments.

    Clinical Features of Amyotrophic Lateral Sclerosis
    What Is Amyotrophic Lateral Sclerosis?
    ALS Signs and Symptoms
    The Different Types of ALS
    ALS: Clinical Case Studies

    Environmental Factors
    What Environmental Factors Are Suspect in ALS?
    Toxic Metals and Solvents
    The Possible Effects of Exercise or Pesticides
    Environmental Influences of Viruses
    BMAA Neurotoxic Effects
    Are Toxins in Seafood Causing ALS?

    Diagnostic Criteria of Amyotrophic Lateral Sclerosis
    Steps in the Diagnosis of ALS
    Electrophysiology in the Revised EEC
    Nerve Conduction Studies
    Clinical Features in the Diagnosis of ALS
    Inconsistent Clinical Features
    ALS Electrophysiological Features
    ALS Neuroimaging Features

    Perspectives of Neuronanomedicine
    Nanomedicine and Neurological Disorders
    CNS Neuroprotective Potentials
    Nanocarriers and CNS-Targeted Drug Delivery
    Applications Based on Cell-Mediated Drug Delivery
    CNS Nano-Based Diagnostic Approaches
    Inflammation and Neurodegeneration: CanWe Measure Neuroprotection and Repair through Imaging Techniques? Constraints in the Treatment of Neurodegenerative Diseases: Future Directions

    Novel Therapeutic Approaches
    Conventional Treatments for ALS
    Occupational Therapy and Supportive Therapy
    Cell Replacement Therapy and Future Challenges
    Stem Cell Transplantation Therapy
    Clinical Applications of Cell Transplant Therapy
    Trials of Other Cell Sources for Stem Cell Therapy
    Stem Cell Therapy: Clinical Trials
    Induced Pluripotent Stem (iPS) Cell Therapy
    Gene Therapy and Future Challenges

    Biography

    Prof Lina Machtoub received her Ph.D. from the University of Tokyo, Japan, 2002, after she was granted honourable research fellowship from the Japanese Government for 5 years. In 2003, she joined Max Planck Institute, Germany, after she was granted a research award from Alexander von Humboldt foundation. In the institute, she worked on the development of combined ultra-high magnetic field and optical imaging. In 2006, she became visiting scientist at Harvard Medical University, Boston. Since 2007, she has participated in several clinical research projects focusing on the development of clinical multimodal imaging techniques based on nanobiotechnology. In 2009, she joined the Medical University of Innsbruck, Austria, where she conducted research on developing highly sensitive, diagnostic, and targeted imaging probes with implications of in vivo imaging-targeted contrast agents and multifunctional imaging. Her main project was the development of innovative diagnostic approach "surface-enhanced coherent anti-Stokes Raman scattering (SECARS) microscopy" using nanoscale contrast agents for magnetic resonance.