Algorithms in Bioinformatics: A Practical Introduction

Wing-Kin Sung

November 24, 2009 by Chapman and Hall/CRC
Textbook - 407 Pages - 16 Color & 225 B/W Illustrations
ISBN 9781420070330 - CAT# C7033
Series: Chapman & Hall/CRC Mathematical and Computational Biology


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  • Presents a comprehensive overview of principles and methods in bioinformatics
  • Covers numerous applications of algorithms in bioinformatics
  • Discusses the practical issues and actual performance of using various methods with real biological data
  • Assumes no prior knowledge of molecular biology
  • Offers PowerPoint slides and other supplementary material on the author’s website

Solutions manual available for qualifying instructors


Thoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions

Developed from the author’s own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation and precisely defines the corresponding computational problems. He also includes detailed examples to illustrate each algorithm and end-of-chapter exercises for students to familiarize themselves with the topics. Supplementary material is available at

This classroom-tested textbook begins with basic molecular biology concepts. It then describes ways to measure sequence similarity, presents simple applications of the suffix tree, and discusses the problem of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of genome rearrangement, and the problem of motif finding. It also covers methods for predicting the secondary structure of RNA and for reconstructing the peptide sequence using mass spectrometry. The final chapter examines the computational problem related to population genetics.