2nd Edition

Adverse Drug Interactions A Handbook for Prescribers, Second Edition

    1216 Pages 2 B/W Illustrations
    by CRC Press

    1216 Pages
    by CRC Press

    Adverse Drug Interactions: A Handbook for Prescribers assists clinicians by providing key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use.

    Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted. Less threatening but nonetheless important interactions necessitating practical measures, such as frequent monitoring and advice to patients, are also discussed.

    Presented in a user-friendly format, the book is organised by drug class and provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse effects occur.

    All interactions listed in the previous edition have been reviewed and updated using the latest information available. The clinical reality of the widespread use of potent medicines, whether allopathic, herbal or traditional, has led to the inclusion of a chapter specifically addressing over-the-counter drugs and remedies.

    Importantly, the increasing relevance of drug interactions due to genetic polymorphisms of metabolizing enzymes and drug transporters and the associated influence of these in ethnic groups is discussed. Also discussed is the risk of interactions in many vulnerable population groups (e.g. infancy, pregnancy, infections, liver and kidney disease).

    This quick and easy reference guide brings together the current evidence base with a broad range of practical prescribing experience to produce a source of advice that can be used in the clinic, pharmacy, or at the patient’s bedside.

    Drugs Acting on the Cardiovascular System
    Simon F.J. Clarke

    Drugs Acting on the Central Nervous System
    Lakshman Delgoda Karalliedde and Harini Genegedera

    Anticancer and Immunomodulating Drugs
    Patrick Yong

    Anticoagulants
    Rebecca Chanda

    Antidiabetic Drugs
    Yohan P. Samarasinghe and Janaka Karalliedde

    Other Endocrine Drugs
    Ming Ming Teh and Yohan P. Samarasinghe

    Analgesics
    Ruwan Parakramawansha

    Musculoskeletal Drugs
    Winglam Yeung

    Anesthetic Drugs: General
    Vasanthi Pinto and E. Queenie Veerasingam

    Drugs to Treat Infections
    Ursula Collignon

    Drugs Acting on the Gastrointestinal Tract
    Ursula Collignon

    Respiratory Drugs
    Lakshman Delgoda Karalliedde and Simon F.J. Clarke

    Metabolic Drugs
    Simon F.J. Clarke

    Obstetrics and Gynecology
    Gregory Ian Giles and Simon F.J. Clarke

    Drugs Used to Treat the Urinary System
    Simon F.J. Clarke

    Drugs of Abuse
    Lakshman Delgoda Karalliedde and Janaka Karalliedde

    Miscellaneous
    Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

    Over-the-Counter/Online Drugs, Traditional and Herbal Remedies
    Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

    Appendices:

    Factors Associated with Drug Effects
    Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

    Factors Associated with Interactions (Polymorphisms, Ethnicity, Age, Disease States)
    Simon F.J. Clarke, Lakshman Delgoda Karalliedde, and Ursula Collignon

    Foods Implicated in Potentially Severe Interactions
    Lakshman Delgoda Karalliedde, Janaka Karalliedde, and Seneka Abeyratne

    Clinical Drug Development
    Lakshman Delgoda Karalliedde and Janaka Karalliedde

    Assessments of Manifestations of DDIs
    Simon F.J. Clarke and Ursula Collignon

    Triptan Sensations
    Lakshman Delgoda Karalliedde and Janaka Karalliedde

    Assessment of Severity of Liver Disease
    Chulananda Goonasekera

    Prescribing Guidelines for Elderly Patients
    Andrea Corsonello and Giuseppe Maltese

    Factors Affecting Efficacy of Anti-Infective Agents
    Niroshini Manthri Giles and Lakshman Delgoda Karalliedde

    Assessments of Obesity
    Lakshman Delgoda Karalliedde and H.M.U. Amila Jayasinghe

    Biography

    Edited by Lakshman Delgoda Karalliedde, visiting professor, Faculty of Medicine Peradeniya, Sri Lanka, and visiting senior lecturer, King's College London, UK Simon Clarke, Frimley Park NHS Foundation Trust, Camberley, UK Ursula Gotel nee Collignon, St. Thomas' Hospital, London, UK Janaka Karalliedde, King's College London School of Medicine, UK

    “There is much to commend. There are useful preliminary sections on the complexity of drug–drug interactions and the emerging role of electronic decision support systems… I was particularly pleased to see the inclusion of interactions with herbal and common over-the-counter medications, alcohol, ‘classic’ recreational drugs, vitamins and minerals, and key food groups.”—Daniel Marks, University College London Hospital, London, British Journal of Hospital Medicine