Advances in Cholesterol Research presents a range of topics which, for the most part, have not been reviewed in recent years in books published on cholesterol. The subject area can be divided into two main sections. The intracellular and extracellular dynamics of cholesterol. The intracellular dynamics of cholesterol includes the intracellular distributions of cholesterol, cellular functions of the sterol, cholesterol metabolism in steroidogenic tissues, the cholestryl ester cycle, relation between cholesterol and dolichol biosynthesis, and the role of cholesterol in tumor cell proliferation. The section on extracellular dynamics of cholesterol includes the biogenesis of high density lipoprotein subclasses, structure-function relation in lecithin: cholesterol acyltransferase, and the role of cholesterol in atherosclerosis and in membrane fusion.
Table of Contents
Intracellular Cholesterol Esterification (J. T. Billheimer and P. J. Gillies). Transmembrane Cholesterol Distribution (Friedhelm Schroeder and George Nemecz). The Biosynthesis of Dolichol and Its Relation to the Control of Cholesterol Synthesis (James W. Doyle and Andrew A. Kandutsch). Role of Cholesterol in Cellular Functions (Phillip L. Yeagle). Lipoprotein and Cholesterol Metabolism in Cells that Synthesize Steroid Hormones (John E. Nestler, Koichiro Takagi and Jerome F. Strauss, III). Intracellular Cholesteryl Ester Hydrolysis and Clearance (Jane M. Glick). The Role of the Cholesterol Synthesis Pathway During Tumor Cell Proliferation (Peter S. Coleman and Laura Sepp-Lorenzino). Lecithin: Cholesterol Acyltransferase (Christopher J. Fielding). Conversions in the Origins and Metabolism of Human Plasma HDL (Alex V. Nichols). Modulation of Membrane Fusion by Cholesterol (Nejat Düzgünes and Demetrios Papahadjopoulos). Role of Cholesterol in Atherosclerosis (Avedis K. Khachadurian). c. 400 pp., hardcover, 1990, ISBN 0-936923-35-0.