This extensive reference/text explores the principles, instrumentation, processes, and programs of pharmaceutical solid science as well as new aspects on one-component systems, micromeritics, polymorphism, solid-state stability, cohesion, powder flow, blending, single- unit sustained release, and tablet coating.
Reveals unique approaches in pharmaceutical solid science not previously published in any other text!
Providing current data on crystallization, dissolution from particles and polydisperse populations, powder volumes and densities, comminution, wet granulation, and hard-shell capsules, Advanced Pharmaceutical Solids
describes moisture isotherms with crystalline solids
documents the effects of moisture on solid-state stability
highlights tablet physics and principles
explains sustained release by microencapsulation
presents prediction equations for solubility in binary solvents
discusses particle sizes and diameters
identifies Brunauer, Emmett, and Teller Isotherms
Considering properties of solids, permeamitry and gas absorption methods, amorphates, and purification by pH-change precipitation, Advanced Pharmaceutical Solids is an essential reference for pharmacists; pharmaceutical scientists; medicinal, physical, surface, colloid, and analytical chemists and biochemists; and an effective text for upper-level undergraduate and graduate students in these disciplines.
Table of Contents
Properties of Solids
Particle Sizes and Diameters
Moisture Isotherms with Crystalline Solids
Drug Substance Considerations
Melting Point Diagrams and Eutectics
Dissolution from Particles and Surfaces
Dissolution from Polydisperse Populations
Effect of Moisture on Solid-State Stability
Apparent Volumes and Densities
Physical Principles of Tablets
Disintegration and Dissolution
Coating of Tablets
Single-Unit Sustained Release Dosage Forms
Sustained Release by Microencapsulation
…a comprehensive overview.
"…would find good use as a textbook in a graduate level course on pharmaceutical solids…equally valuable as an information source for anyone seeking a brief overview of a particular area.
"-Pharmaceutical Development Technology
"…deserves a place on the bookshelves of any pharmaceutical scientist working on the development of solid dosage forms….
…an excellent initial reference for advanced students and scientists working on solids.