Adaptive Optics for Biological Imaging

Joel A Kubby

April 26, 2013 by CRC Press
Reference - 388 Pages - 242 B/W Illustrations
ISBN 9781439850183 - CAT# K12282


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  • Provides the only comprehensive treatment of the principles, methods, and applications of adaptive optics in microscopy for biological imaging
  • Focuses on biological imaging and synthesizes research from the first decade of this emerging field
  • Takes an interdisciplinary perspective, making the material accessible to nonspecialists without a background in applied optics
  • Shows how to use adaptive optics in the microscopy of biological samples to improve image quality and provide deeper tissue imaging
  • Discusses how the wide availability of MEMS components has enabled applications of adaptive optics in biological imaging
  • Includes more than 240 illustrations, plus a 12-page color insert


Adaptive Optics for Biological Imaging brings together groundbreaking research on the use of adaptive optics for biological imaging. The book builds on prior work in astronomy and vision science. Featuring contributions by leaders in this emerging field, it takes an interdisciplinary approach that makes the subject accessible to nonspecialists who want to use adaptive optics techniques in their own work in biology and bioengineering.

Organized into three parts, the book covers principles, methods, and applications of adaptive optics for biological imaging, providing the reader with the following benefits:

  • Gives a general overview of applied optics, including definitions and vocabulary, to lay a foundation for clearer communication across disciplines
  • Explains what kinds of optical aberrations arise in imaging through various biological tissues, and what technology can be used to correct for these aberrations
  • Explores research done with a variety of biological samples and imaging instruments, including wide-field, confocal, and two-photon microscopes
  • Discusses both indirect wavefront sensing, which uses an iterative approach, and direct wavefront sensing, which uses a parallel approach

Since the sample is an integral part of the optical system in biological imaging, the field will benefit from participation by biologists and biomedical researchers with expertise in applied optics. This book helps lower the barriers to entry for these researchers. It also guides readers in selecting the approach that works best for their own applications.