1st Edition

Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies

    148 Pages 38 B/W Illustrations
    by CRC Press

    This book covers the computer simulation of demyelinating neuropathies and neuronopathies and compares models with clinical findings. Through the approximation of nerve excitation and conduction, the authors show how the versatile structure of nerve fibers relates to different modes of focal prospects, inward and outward currents, conduction velocity, and errant transmission. They also explain how mathematical models elucidate emerging fine distinctions between hereditary and acquired neuronal diseases, including Charcot-Marie-Tooth, chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, multifocal motor neuropathy, and amyotrophic lateral sclerosis.

    Preface
    Abbreviations

    Nerve Fibres
    Myelinated Axons
    Demyelinating Neuropathies
    Neuronopathies
    Axonal Excitability
    Mathematical Modeling of Nerve Fibres
    Models and Methods for Investigation of the Human Motor Nerve Fibre
    Multi–Layered and Double Cable Models
    Line-Source Model
    Methods of Stimulation and Calculation of the Potentials (Action, Electrotonic and Extracellular)
    Methods for Calculation of the Strength-Duration Time
    Constants, Rheobasic Currents and Recovery Cycles
    Simulated Demyelinating Neuropathies and Neuronopathies
    Simulation of CMT1A, CIDP, CIDP Subtypes, GBS, MMN and ALS
    Abnormalities in the Potentials
    Action Potentials
    Electrotonic Potentials
    Abnormalities in the Extracellular Potentials and their Mechanisms
    Abnormalities in the Strength-Duration Time Constants Rheobasic Currents and their Mechanisms
    Abnormalities in the Recovery Cycles and their Mechanisms
    Effect of Myelin Sheath Aqueous Layers on the Excitability Properties of Simulated Hereditary and Chronic Demyelinating Neuropathies
    Simulation of CMT1A, CIDP and CIDP Subtypes with Aqueous Layers within the Myelin Sheath
    Effect of Myelin Sheath Aqueous Layers on the Potentials
    Effect of Myelin Sheath Aqueous Layers on the Strength-Duration Time Constants, Rheobasic Currents
    and Recovery Cycles
    References
    Index

    Biography

    Stephanova, Diana Ivanova; Kolev, Bozhidar Dimitrov