This book provides an actual overview of structure, function, and application of carbohydrate-modifying biocatalysts. Unlike amino acids and nucleic acids, carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure and a lack of suited experimental methods for structure determination. Meanwhile, the situation changed with increasing knowledge about carbohydrates, glycoconjugates, and carbohydrate-modifying enzymes together with the key roles they play in biological processes such as recognition, signal transduction, and immune responses. An outcome of research activities in glycoscience, which, at the same time, is of great general interest, is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases.
Basics in Carbohydrate Chemistry, H. Hühnerfuss
Glycoconjugates: An Overview, P. Grunwald
Oligosaccharides and Glycoconjugates in Recognition Processes, T. K. Lindhorst
Glycoside Hydrolases, M. Kitaoka
Disaccharide Phosphorylases: Mechanistic Diversity and Application in Glycosciences, C. Luley-Goedl and B. Nidetzky
Enzymatic and Chemo-Enzymatic Synthesis of Nucleotide Sugars: Novel Enzymes, Novel Substrates, Novel Products, and Novel Routs, L. Engels and L. Elling
Iteratively Acting Glycosyltransferases, M. Luzhetska and A. Bechthold
Bacterial Glycosyltransferases Involved in Molecular Mimicry of Mammalian Glycans, W. Wakarchuk
Sulfotransferases and Sulfatases: Sulfate Modification of Carbohydrates, Eli Chapman and Sarah R. Hanson
Glycosylation in Health and Disease, P. Grunwald
Sialic Acid Derivatives, Analogs and Mimetics as Biological Probes and Inhibitors of Sialic Acid Recognizing Proteins, J. Tiralongo and T. Haselhorst
Enzymes of the Carbohydrate Metabolism and Catabolism for Chemoenzymatic Syntheses of Complex Oligosaccharides, J. Thimm and J. Thiem
From Gene to Product — Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering, J. Seibel
Synthesis and Modification of Carbohydrates via Metabolic Pathway Engineering in Microorganisms, X.-W. Liu, L. Li, H.-T. Gao, L.-J. Dang, and P. G. Wang
Metabolic Pathway Engineering for Hyaluronic Acid Production, E. Marcellin, Wendy Y. Chen, and L. K. Nielsen
Microbial Rhamnolipids, M. M. Müller, B. Hörmann, C. Syldatk, and R. Hausmann
Chitin-Converting Enzymes, K. Moß, S. Zibek, T. Hirth, and S. Rupp
Linear and Cyclic Oligosaccharides, H. Taniguchi
Fungal Degradation of Plant Oligo- and Polysaccharides, R. P. de Vries, M. Nadal, J. van der Brink, D. A. Vivas-Duarte, and H. Stålbrand
Bacterial Strategies for Plant Cell Wall Degradation and Their Genomic Information, Y. Tamaru and R. H. Doi
Design of Efficient Multi-Enzymatic Reactions for Cellulosic Biomass Processing, Anne S. Meyer
Biography
Peter Grunwald
"This is an excellent compilation of the latest research in the field of carbohydrate-modifying biocatalysts written by highly recognized experts in the field. With glycoscience and biocatalysis emerging as fundamental contributors to a diverse array of scientific disciplines ranging from pharmaceutical development to renewable energy, this book is particularly timely and should serve as an excellent reference for inspiring scientists and students."
—Prof. Jon S. Thorson - University of Wisconsin School of Pharmacy, USA