Tyrosine hydroxylase is the rate-limiting enzyme in the biosynthesis of catecholamines. Since the discovery of this enzyme by Dr. Toshiharu Nagatsu, the enzyme has been intensively studied in relation to both its physiological function in the brain and brain disorders. Especially the successful application of L-DOPA therapy for Parkinson's disease suggests that this enzyme should have a primary role in the progress of this disease. As a tribute to Dr. Toshiharu Nagatsu, this book presents an overview of research on this important enzyme, from molecular to clinical aspects. The book also includes the latest results on functional and clinical aspects of the enzyme. It provides as insight in how the enzymatic and biochemical study of this monooxygenase has led to the understanding of many diseases such as Parkinson's disease, stress and emotional disorders.
EDITORIAL Toshiharu Nagatsu -- A tribute on his 60th birthday TYROSINE HYDROXYLASE: ITS PROPERTIES AND THE REGULATION OF THE ACTIVITY Tyrosine Hydroxylase: Historical reflections T. Nagatsu Tyrosine Hydroxylase and factors influencing its activity S. Udenfriend The influence of nerve growth factor on the level and activity of Tyrosine Hydroxylase G. Guroff Allosteric regulation of Tyrosine Hydroxylase activity by its cofactor tetrahydrobiopterin M. Naoi, M. Minami, W. Maruyama and H. Parvez Non-catecholaminergic neuronal expression of human Tyrosine Hydroxylase in the brain of transgenic mice with special reference to aromatic L-amino acid decarboxylase I. Nagatsu, K. Yamada, N. Karasawa, N. Kaneda, T. Sasaoka, K. Kobayashi, K. Fujita and T. Nagatsu Regulation of Tyrosine Hydroxylase by adenosine derivatives in adrenal chromaffin cells; long-term induction of gene expression and short-term modulation of enzyme activity Y. Kuroda, K. Muramoto and K. Kumakura Amine synthesizing enzymes, peptides, growth factors and oncogene products in midgut carcinoid tumours and pheochromocytomas in tissue culture H. Ahlman, A. DahlstrÃ¶m, M. Goldstein, S. Jansson, A. McRae, O. Nilsson and B. WÃ¤ngberg Developmental changes in Tyrosine Hydroxylase in periphery H. Kuzuya Enzyme immunoassay of Tyrosine Hydroxylase M. Mogi and M. Harada Monitoring of Tyrosine Hydroxylase activity in conscious rat striatum with a microdialysis T. Kato, S. Hisamatsu and M. Xu Purification of Tyrosine Hydroxylase K. Kojima TYROSINE HYDROXYLASE: ITS MOLECULAR STUDIES Progress in Tyrosine Hydroxylase gene research T.H. Joh Multiplicity of human cDNAs of Tyrosine Hydroxylase K.L. O'Malley The human Tyrosine Hydroxylase gene T. Nagatsu, N. Kaneda, K. Kobayashi, H. Ichinose, T. Sasaoka, K. Kiuchi, K. Fujita and Y. Kurosawa TYROSINE HYDROXYLASE: ITS INVOLVEMENT TO DISEASES Clinical evaluation of Tyrosine Hydroxylase activity in brain and peripheral organs I.J. Kopin Decrease of Tyrosine Hydroxylase activity and understanding of Parkinson's disease H. Narabayashi Tyrosine Hydroxylase in Parkinson's disease W.-D. Rausch and P. Riederer Biogenic amines in cerebral ischemia and trauma M. Spatz, H.M. Pappius and B.B. Mrsulja Stress-induced changes in Tyrosine Hydroxylase and other catecholamine biosynthetic enzymes R. Kvetnansky and E.L. Sabban Tyrosine Hydroxylase in nigrostriatum and hypothalamus: Linkage to the cardiovascular system N. Alexander Hypertension in rats fed a low calcium diet: Roles of catecholamine synthesis and secretion A. Togari