Advanced Drug Delivery Nanoparticles
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Summary
Nanotechnology offers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer length scales and is expected to have a revolutionary impact on biology and medicine. This book introduces new research on intelligent drug delivery systems for cancer therapy. The book covers recent developments in nanoparticulate drug delivery systems (NPDDS). The book then addressess the formulation of aspects covering small molecules, macromolecules, gene delivery, protein-based nanodelivery systems, therapeutic and diagnostic applications of gold nanoparticles, and the application of NPDDS in cancer, diabetes, and dermal and transdermal deliveries.
Table of Contents
Oral Delivery Systems
Colon Targeted Drug Delivery Systems. Structure of Colon. Absorption of Drugs from the Colon. pH of Various Area of Gastrointestinal Region. Colonic Diseases. Drugs Used in Colon Cancer. New Targeted Drug Delivery Systems. Bibliography.
Mucosal Delivery Systems
Nasal Delivery Systems. Drug Distribution. Drug Absorption. Nasal Delivery Systems. Drug Distribution. Drug Absorption. Biological Factors. Physiological Factors. Various Approaches Used for Intranasal Drug Delivery. Excipients Used to Improve the Absorption of Drugs. Bibliography.
Mucoadhesive Vaginal Delivery Systems
Mucoadhesive Vaginal Gels. Gels for the Moisturization of Vagina. Gels for the Treatment of Vaginal Infections. Gels for Contraception. Formulations Based on Cellulose Derivatives and Chitosan. Formulations Based on Thermosensitive Polymers. Mucoadhesive Vaginal Tablets. Mucoadhesive Vaginal Films. Emulsion Type Mucoadhesive Vaginal Systems. Vaginal Suppositories. Mucoadhesive Vaginal Systems for Systemic Effect. Bibliography.
Mucoadhesive Rectal Drug Delivery Systems
Special Populations. Clinical Studies. Microspheres Based on Gelatin-Mucin Admixtures for the Rectal Delivery. Development of in situ Gelling and Mucoadhesive Mebeverine Hydrochloride Solution for Rectal Administration. Bibliography.
Mucoadhesive Buccul Delivery Systems
Structure And Function of Oral Mucosal Membrane. Permeation Enhancers. Mechanisms of Action. Buccal Mucoadhesive Polymers. Ideal Characteristics of A Buccal Adhesive Polymer. Mucoadhesion Theories of Polymer Attachment. The Wettability Theory. Mucoadhesive Polymeric Platforms. First-Generation Mucoadhesive Polymers. Novel Second-Generation Mucoadhesive Polymers. Factors Affecting Mucoadhesion. Advantages of Mucoadhesive Buccal Drug Delivery System. Buccal Mucosa as a Site for Drug Delivery. Methodology for Buccal Permeation Studies. In Vitro Methods. In Vivo Methods. Experimental Animal Species. Buccal Permeation Enhancement. Buccal Drug Delivery Systems. Bibliography.
Mucoadhesive Ocular Delivery Systems
Modes of Administration, Barriers, and Their Signification in Ocular Drug Delivery. Transporters in Eye. Colloidal Dosage Forms for Ocular Drug Drug Delivery. Microneedle, Ultrasound, and Intophoresis-Based Ocular Drug Delivery Systems. Vesicular System. Control Delivery Systems. Advanced Delivery Systems. Bibliography.
Transdermal Delivery Systems
Types of Transdermal Patches. Various Methods for Preparation TDDS. Evaluation Parameters. Polymers in Transdermal Drug Delivery Systems. Bibliography.
Inhalation Delivery Systems
Formulation Technology. Delivery by Inhalation. Combination Production Development, Device Design. Advancing Combination Product Development Through Patient Profiling. Technology Exemplified in Afezza (Technosphere Insuline). Clinical Trial Results. Bibliography.
Pulmonary Delivery Systems
Ideal Characteristics of Therapeutic Aerosol. Advantages of Pulmonary Drug Delivery. Challenges in Pulmonary Drug Delivery. Recent Advances in Pulmonary Drug Delivery Includes. Recent Technologies Used in Pulmonary Drug Delivery. Advances in MDI Technology and Use Enantiomer Preparations of Inhaled Drugs. Generic Proliferation of Devices and Medications. New Technologies to Improve Patient’s Inhalation Coordination with Mdi. Flow Gate Valve Technology in Spacers. The Autohaler Modified Form of pMDI. Recent Advances Pulmonary Drug Delivery Devices. Advances in MDI Technology and Use Enantiomer Preparations of Inhaled Drugs. Generic Proliferation of Devices and Medications. New Technologies to Improve Patient’s Inhalation Coordination With Mdi. New Developments in Dry Powder Inhalation Technology. Recent Advances in Formulation of Pulmonary Drug Delivery. Advances in Propellants Used in Pulmonary Drug Delivery Devices. New Applications of Pulmonary Drug Delivery. Bibliography.
Drug Delivery Systems for Cancer Therapy
Cancer Disease. Biomarkers of Cancer. pH-Dependent Glycol Chitosan and Dextran Sulfate Nanoparticles for Effective Brain Cancer Treatment. Biodegradable Modified Chitosan Nanoparticles for Photodynamic Treatment of Cancer. A Novel Superparamagnetic Chitosan Hydrogel/Chlorin E6 Nanocarriers. Bibliography
Bibliography.
Author Bio(s)
M. R. Saboktakin, PhD, was formerly researcher and Director Manager at Faravar Chemie Tara Engineering Company, Tabriz, Iran, as well as researcher and Director Manager at the International Research Institute of Arian Chemie Gostar, Tabriz, Iran. He has published many articles in professional journals, has participated in many international conferences, and has also contributed to several books. His research interests include synthesis of novel photosensitizer nanoparticles for photodynamic therapy; synthesis and characterization of nanocomposites, nanomaterials, nanoparticles, and novel drug delivery systems; synthesis and characterization of new conductive nanocomposites, new dendritic drug nanocarriers, superparamagnetic nanocomposities as anti-cancer nanocarriers, and new groups of superconductives using nanomaterials; and the development of drug delivery systems, dendrimers, conductive nanocomposites, and superconductors.
Editorial Reviews
"In the last decade or so, there has been an explosion of interest in nanoscience and nanotechnology. Scientists from different disciplines (physics, chemistry, biology, medicine, engineering, materials science, etc.) are embracing this new field, each bringing his or her expertise and modus operandi. As far as the contribution of chemistry (and chemists) to nanoscience is concerned, strong emphasis is placed on the preparation and characterization of the building blocks (molecules and nanoparticles) necessary to synthesize nanostructured materials following a bottom-up approach. In this regard, all chapters of this book are concerned with the most popular materials used in contemporary nanochemistry. Fundamental concepts that are discussed in this book are those of size and shape as well as the bionano interface and self-assembly. Overall, the book provides a good overview on modern nanochemistry that will benefit students as well as scientists interested in broadening their knowledge."
—Kaveh Hariri Asli, PhD, National Academy of Science of Azerbaijan "AMEA," Baku, Azerbaijan
