Age-Related Macular Degeneration, Third Edition

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ISBN 9781841849492
Cat# H100304



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    • Provides an in-depth review and analysis of the management of dry and wet AMD, including medical and surgical treatment
    • Includes research advances that have resulted in novel therapies
    • Discusses strategies to prevent the progression of non-exudative AMD
    • Summarizes studies and results from current clinical trials
    • Includes more than 200 clinical photographs and illustrations—many in full color


    The value of Age-Related Macular Degeneration has stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, mandating the need for an updated book. This second edition focuses on the pathophysiology and the epidemiology of age-related macular degeneration (AMD), the clinical features and management of dry and wet AMD, imaging techniques, and medical therapy for both non-neovascular AMD and neovascular AMD. It describes both clinically validated and experimental therapies as well as rehabilitation technology, and presents strategies to prevent the progression of non-exudative AMD. Results from current clinical trials are also included.

    New chapters in this edition cover:

    • Genetics and treatment
    • Oxidative stress and its relation to the pathophysiology of AMD and CNV (choroidal neovascularization—a common symptom of wet AMD)
    • Polypoidal choroidal vasculopathy
    • Microperimetry and psychophysical testing and ways to track geographic atrophy progression
    • Non-VEGF pathways
    • Retinal stem cells

    Table of Contents

    Pathophysiology and Epidemiology of AMD
    Histopathology of Age-Related Macular Degeneration
    Immunology of Age-Related Macular Degeneration
    Genetics of Age-Related Macular Degeneration
    Choroidal Neovascularization: VEGF Pathways
    Risk factors for Age-Related Macular Degeneration and Choroidal Neovascularization
    Oxidative Stress
    Clinical Features of AMD
    Geographic Atrophy
    Non-Neovascular Age-Related Macular Degeneration
    Neovascular Age-Related Macular Degeneration
    Polypoidal Choroidal Vasculopathy
    Variants of Neovascular Age-related Macular Degeneration: Type 3 Neovascularization (Intra-retinal Neovascularization or Retinal Angiomatous Proliferation)
    Imaging Techniques for the Clinical Evaluation of AMD
    Fluorescein Angiography in Age-related Macular Degeneration
    Indocyanine Green Angiography in Age-Related Macular Degeneration
    Optical Coherence Tomography in the Evaluation of Age-Related Macular Degeneration
    How to Analyze OCT images for Management of Neovascular AMD
    Fundus Autofluorescence Imaging in Age-Related Macular Degeneration
    Microperimetry and Psychophysical Testing to Aid in Determination of Progression of AMD
    Current and Experimental Medical Treatment for Neovascular AMD
    Laser Photocoagulation for Choroidal Neovascularization
    Anti-VEGF drugs and Clinical trials
    Non-VEGF Related Anti-Angiogenesis Pathways for Treatment of AMD
    Radiation Therapy Treatment in Age-Related Macular Degeneration
    Combination Therapy for AMD
    Photodynamic Therapy for Neovascular AMD
    Photocoagulation of AMD-Associated CNV Feeder Vessels
    Macular Translocation and Other Surgical Treatments
    Current and Experimental Medical Treatment for Non-Neovascular AMD and Geographic Atrophy
    Prophylactic Treatment: The AREDS Study Results
    Visual Cycle Modulation
    Cellular Transplantation for Advanced Age-Related Macular Degeneration
    Novel Therapeutic Interventions: Stem Cell
    Rehabilitation of the Eye
    Clinical Considerations for Visual Rehabilitation
    Visual Prostheses for Age-Related Macular Degeneration
    Development of Research Protocols in AMD
    Clinical Research Trials

    Editor Bio(s)

    Jennifer I. Lim, M.D. is a professor of ophthalmology, Department of Ophthalmology; Director of the Retina Service; Marion H. Schenk, Esq. Chair in Ophthalmology for Research of the Aging Eye, at the University of Illinois at Chicago.

    Dr Lim has contributed to over 90 courses, and has published over 200 academic papers, contributed to over 20 book chapters and published 4 books in total. She has given over 150 presentations at scientific meetings and has been invited to over 130 lectures/visiting professorships. Dr Lim is a reviewer for a number of academic journals including the American Journal of Ophthalmology, Retina, and the British Journal of Ophthalmology. She is currently a committee member for the Macula Society, American Society of Retinal Specialists, and American Academy of Ophthalmology.

    Recent Awards:

    •Marion H. Schenk, Esq., Chair in Ophthalmology for Research of the Aging Eye, 2010
    •Best Doctors in America 2010-2011 (initially and continuously selected since 1994)