Coronary Atherosclerosis: Current Management and Treatment

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Summary

The prevalence of coronary artery disease is increasing due to rising rates of obesity and the fact that a greater number of people are living longer. Coronary Atherosclerosis: Current Management and Treatment addresses this leading cause of death worldwide.

Atherosclerosis has a broad range of disease manifestations depending on the degree of the stenosis and the functional status of the coronary plaque. This volume, written by a leading international team of editors, addresses the pathophysiology of the disease, established and novel diagnostic approaches (both invasive and non-invasive), treatment methodologies (including treatment algorithms), and differing perspectives on treatment, including future therapies and long-term outcomes. The inclusion of personal perspectives from experts, full-color images and ancillary video files make this a key resource.

Key topics include:

  • Pharmacology of coronary artery disease (CAD)
  • Up-to-date evidence on pathophysiology
  • Invasive and non-invasive imaging
  • Current evidence for risk stratification
  • Clinical decisionmaking

Coronary Atherosclerosis: Current Management and Treatment provides a state-of-the-art review of current knowledge to aid specialists, general physicians, and cardiologists in training, in the diagnosis, risk stratification, and management of patients with diverse presentations of coronary atherosclerosis.

Table of Contents

The Pathophysiology of Coronary Atherosclerosis
Current concepts of plaque formation and the progression of atherosclerosis
Masataka Nakano, MD., Renu Virmani, MD., and Frank D. Kolodgie, PhD
Screening and identifying the high risk individuals in the general population by using traditional risk factors
Gregory Angelo Sgueglia, MD, PhD, Gaetano Antonio Lanza, MD, Filippo Crea, MD
The role of genomics and proteomics in identifying subjects at risk of clinical manifestations of coronary atherosclerosis and their future clinical applications
Carlos L. Alviar MD, Pedro R. Moreno MD
The identification of the patient at risk using biomarkers: Current status and evolving avenues for research
Gerard Pasterkamp, Imo Hoefer, Dominique de Kleijn
Stable and unstable atherosclerotic disease: definitions, clinical manifestations and pathophysiology
John A Ambrose, MD FACC, Joel A. Lardizabal, MD

Diagnostic Approach to Coronary Atherosclerosis: Non Invasive Approach
Clinical evaluation of the patient with chest pain
Attilio Maseri
Exercise stress testing, stress echocardiography, and scintigraphy: which tool for which patient?
Arend F.L. Schinkel, MD, PhD, and Manolis Bountioukos, MD, PhD, FES
Multislice Computed Tomography: Role in diagnosis and risk stratification
G.J.R. ten Kate MD, MSc, K. Nieman MD, PhD, P.J. de Feyter MD, PhD
Magnetic resonance imaging: Role in diagnosis and risk stratification
Pier Giorgio Masci MD and Jan Bogaert MD PhD
CT-PET: Role in diagnosis and potential to predict the response to revascularization
Marcelo F. di Carli, Dr. Koh

Diagnostic Approach to Coronary Atherosclerosis: Invasive Approach
From conventional to 3-dimension coronary angiography: potential clinical
Chrysafios Girasis, MD
Fractional flow reserve: Role in guiding clinical decision making [video content also supplied]
Bernard De Bruyne, Aaron Peace, Stylianos A. Pyxaras
Intravascular ultrasound: Role in diagnosis and management [video content also supplied]
Kenji Sakamoto MD; Yasuhiro Honda MD; Peter J. Fitzgerald MD, PhD
Photoacoustic Imaging of Coronary Arteries: current status and potential clinical application
Krista Jansen, Gijs van Soest PhD, Ton van der Steen PhD
Plaque imaging with optical coherence tomography: Current status and potential clinical implications
Francesco Prati, Eleonora Ficarra, Vito Ramazzotti, Mario Albertucci
Thermal assessment of the human coronary atherosclerotic plaque: Current status and potential clinical implications
Konstantinos Toutouzas, Maria Drakopoulou, Archontoula Michelongona, Eleftherios Tsiamis, Christodoulos Stefanadis
Imaging of Structure and Composition of Lipid Core Plaque with a Combination NIRS-IVUS System: Current Status and Potential Clinical Applications
Emmanouil S. Brilakis, MD, PhD, Zhihua He, PhD, Stephen T. Sum, PhD, Sean P. Madden, PhD, James E. Muller, M.D.
Role of Endothelial Shear Stress in the Destabilization of Coronary Plaque: Acute Coronary Syndromes and Rapid Plaque Progression
Antonios P. Antoniadis, MD, PhD, Michail I. Papafaklis, MD, PhD, Saeko Takahashi, MD, Charles L. Feldman, ScD, Peter H. Stone, MD
Tissue characterization using virtual histology and iMAP: Current status and potential clinical applications
Salvatore Brugaletta, MD; Hector M. Garcia-Garcia, MD, PhD
The role of angioscopy in the assessment of the atherosclerotic plaque: Current status and potential clinical applications [video content also supplied]
Yasunori Ueda, MD, PhD; Kazuhisa Kodama, MD, PhD
What is the optimal imaging tool for coronary atherosclerosis?
Takashi Kubo, MD, PhD; Takashi Akasaka, MD, PhD

Treatment methodology of coronary artery disease
Optimization of primary and secondary prevention
Katerina K. Naka MD, PhD, FESC, ,Aris Bechlioulis MD, Lampros K. Michalis MD, MRCP (UK), FESC
Anti-ischemic pharmacotherapy in patients with established coronary artery disease
Dimitrios Alexopoulos MD, FESC, FACC, Ioanna Xanthopoulou MD
Antithrombotic pharmacotherapy in patients with established coronary artery disease
Antonio Tello-Montoliu, MD, PhD; Dominick J Angiolillo, MD, PhD
Invasive assessment and management of intermediate coronary narrowings
William F. Fearon, M.D.
Treatment algorithm in patients with stable angina
Andrew Cassar, M.D., M.R.C.P. *Bernard J. Gersh, M.B., Ch.B., D.Phil, F.R.C.P.
Treatment algorithm in patients with NSTEMI and unstable angina
Francesco Saia, MD, PhD
Treatment algorithm in patients with STEMI
Luca Golino MD, PhD, Giuseppe De Luca MD, PhD
Management of microvascular angina
Juan Carlos Kaski, MD, DSc, Peter Ong, MD
Treatment algorithm in patients with concomitant heart valve disease
Vassilis Voudris MD FESC FACC, Panagiota Georgiadou MD

Treatment approach to coronary artery disease: Diverse perspectives
Clinical Perspectives on the Management of Advanced Stable Coronary Disease
Ranil de Silva PhD FRCP and Kim Fox MD FRCP
Interventional Perspectives on the Management of Advanced Stable Coronary Artery Disease [video content also supplied]
Joanne Shannon MD, Azeem Latib MD, Antonio Colombo MD
Surgical perspectives on the Management of Advanced Stable Coronary Artery Disease
Michael J. Mack MD, Arie Pieter Kappetein, M.D., Ph.D., Stuart Head, MS
Hybrid treatments and future perspectives [video content also supplied]
G. Russell Reiss MD and Mathew R. Williams MD
Determinants of long term outcome following percutaneous coronary intervention
Pedro A. Lemos MD PhD
Determinants of long term outcome following bypass surgery
Arie Pieter Kappetein, M.D., Ph.D., Stuart Head, M.Bsc
Novel therapeutic approaches to prevention and regression of atherosclerosis
Kuang-Yuh Chyu, MD, PhD, Prediman K. Shah, MD

Editor Bio(s)

Chourmouzios Arampatzis, MD, PhD,FESC, Senior Interventional Cardiologist, Interbalkan Medical Center, Thessaloniki, Greece

Eugene P. McFadden MB, BCh, BAO, DCH, MRCP(UK), FRCPI, FESC, FACC, Thoraxcenter, Erasmus University Medical Centre, Rotterdam, The Netherlands and Interventional Cardiologist, Cork University Hospital, Wilton, Cork, Ireland

Lampros K. Michalis MD, Professor in Cardiology, Department of Cardiology, Medical School, University of Ioannina, Greece

Renu Virmani, M.D, President and Medical Director, CVPath Institute, Inc., Gaithersburg, Maryland, USA

Patrick W. Serruys MD, Head of the Interventional Dept., Heartcenter Rotterdam, Rotterdam, The Netherlands