Cancer Biomarkers

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ISBN 9781578087617
Cat# K16340

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Summary

This unique synthesis of chapters from top experts in their fields targets the essential area of cancer biomarkers and the need for better and more rigorous design and clinical trials. The contributors cover several aspects of cancer molecular markers from innovation and screening to their controversies and future directions. The book is an ideal reference for PhD and MD students, researchers, biologists, medical doctors, and professionals who are interested in mechanistic studies on cancer diagnosis and translational benefits from personalized cancer treatment using the new era of biomarkers.

Table of Contents

Improving Research on Biomarkers for Early Detection and Screening of Cancers
Claire S. Zhu, Paul F. Pinsky, and Christine D. Berg
Biomarkers of Oxidative Stress in Carcinogenesis
Humberto Rodriguez-Rocha, Aracely Garcia-Garcia, and Rodrigo Franco
β-Catenin: a Novel Biomarker and Therapeutic Target in Liver Cancer
Anupam Bishayee
Urine Biomarkers for Prostate Cancer Detection
Yan-Hua Chen, Art A. Rodriguez, and Qun Lu
Ectodomain Shedding as a Mechanism to Generate Cancer Biomarkers (Ectomarkers)
Maria J. Ruiz-Echevarria, Xiaofei Chen, and Ryan F. Overcash
The BRCT Signaling ‘landscape’: Emerging Concepts and Implications in Tumorigenesis and Cancer Diagnostics
Dimitris Mastellos and George Nounesis
Cellular Senescence and Cancer Development: Antagonistic and Synergistic Relations
Dimitris Kletsas
Micro-RNAs: From Regulators of Gene Expression to Cancer Biomarkers
Stamatina Giannouli, Panagiotis Maragozidis, Konstantinos I. Gourgoulianis, and Nikolaos A.A. Balatsos
Targeting PARP-1 in Breast Cancer: The Paradigm of a DNA Repair-based Therapeutic Strategy
Francisco Javier Oliver, Jara Majuelos-Melguizo, José Manuel Rodriguez-Vargas, Ariannys González-Flores, A. Peralta-Leal, Laura López, and María Isabel Rodríguez
Statins in Prostate Cancer: Prevention and Treatment
Khaled Aziz and Phuoc T. Tran
Mechanistic Aspects of Oxidative Stress Involvement in Human Environmental and Occupational Carcinogenesis
Dominique Ziech, Aglaia Pappa, and Mihalis I. Panayiotidis