Scaffolding In Tissue Engineering

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Features

  • Lays the fundamental principles behind reconstructing biologically functional tissues and organs
  • Brings together a large number of experts in engineering, life sciences, and clinical medicine with various tissue engineering expertise
  • Evaluates the latest materials and their biological interaction
  • Studies how synthetic materials are manufactured
  • Describes how scaffold structure can be modified to perform a specific biological function
  • Surveys the various kinds of tissue that synthetic materials can replicate or regenerate
  • Summary

    The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

    Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and concentrates on the principles, methods, and applications for a broad range of tissue engineering scaffolds. The first section presents an in-depth exploration of traditional and novel materials, including alginates, polysaccharides, and fibrillar fibrin gels. The following section covers fabrication technologies, discussing three-dimensional scaffold design, laboratory-scale manufacture of a cell carrier, phase separation, self-assembly, gas foaming, solid freeform fabrication, injectable systems, and immunoisolation techniques. Subsequent chapters examine structural and functional scaffold modification, composite scaffolds, bioactive hydrogels, gene delivery, growth factors, and degradation of biodegradable polymers. The final section explores various tissue engineering applications, comprising chapters on blood cell substitutes, and tissue engineering of nerves, the tendons, ligaments, cornea, cartilage and myocardium, meniscal tissue.

    While providing a comprehensive summary of current knowledge and technologies, Scaffolding in Tissue Engineering gives readers insight into new trends and directions for scaffold development and for an ever-expanding range of tissue engineering applications.

    Table of Contents

    SCAFFOLDING MATERIALS
    Biologically Active Scaffolds based on Collagen-GAG Copolymers; Ioannis V. Yannas
    Alginate for Tissue Engineering; Peter X. Ma
    Polysaccharides Scaffolds for Tissue Engineering; Tirtsa Ehrenfreund-Kleinman, Jacob Golenser, and Abraham J. Domb
    Role of Gelatin in the Release Carrier of Growth Factor for Tissue Engineering; Yasuhiko Tabata
    Fibrillar Fibrin Gels; Erin Grassl and Robert T. Tranquillo
    Photopolymerization of Hydrogel Scaffolds; Stephanie J. Bryant and Kristi S. Anseth
    Poly(ortho esters); J. Heller, J. Barr, D.T. Shah, S.Y. Ng, H.-R Shen, and B.B. Baxter

    SCAFFOLD FABRICATION TECHNOLOGIES
    Salt-Leaching for Polymer Scaffolds: Laboratory-Scale Manufacture of Cell Carriers; Joerg K.V. Tessmar, Theresa A. Holland, and Antonios G. Mikos
    Phase Separation for Polymer Scaffolds; Victor J. Chen and Peter X. Ma
    Solid Freeform Fabrication of Tissue Engineering Scaffolds; Tien-Min G. Chu
    Gas Foaming to Fabricate Polymer Scaffolds in Tissue Engineering; Yen-Chen Huang and David J. Mooney
    Injectable Systems for Cartilage Tissue Engineering; Christopher G. Williams and Jennifer H. Elisseeff
    Immunoisolation Techniques; Beth Anne Zielinskip
    Self-Assembled Monolayers in Mammalian Cell Cultures; Xingyu Jiang, Jassamine Ng Lee, and George M. Whitesides
    PuraMatrix: Self-assembling Peptide Nanofiber Scaffolds; Shuguang Zhang, Xiaojun Zhao, and Lisa Spirio

    MATERIALS MODIFICATIONS AND PROPERTIES
    Polymer/Ceramic Composite Scaffolds; Guobao Wei, Peter X. Ma
    Polymer/Calcium Phosphate Scaffolds; Cato T. Laurencin and Yusuf Khan
    Hydroxyapatite/Collagen Scaffolds; Chang Du, Fu-Zhai Cui, and Klaas de Groot
    Bioactive Hydrogels: Mimicking the ECM with Synthetic Materials; Jennifer West
    Albumin Modification; Sang Cheon Lee, Yoon Yeo, and Kinam Park
    Modified Alginates for Tissue Engineering; Yen-Chen Huang and David Mooney
    Gene Delivery in Regenerative Medicine; Kam W. Leong
    Degradation of Biodegradable Aliphatic Polymers; Suming Li

    TISSUE ENGINEERING APPLICATIONS
    Biomaterials for Genitourinary Tissue Engineering; Priyabrata Mukherjee and Anthony Atala
    Engineered Blood Vessel Substitutes; Jan P. Stegemann, Shaneen L. Rowe, and Robert M. Nerem

    Tissue Engineering of Tendon and Ligament; Changming Guo and Myron Spector
    Tissue Engineering of the Cornea; May Griffith, Fengfu Li, Chris Lohman, Heather D. Sheardown, Shigeto Shimmura, and David J. Carlsson
    Materials Employed for Breast Augmentation and Reconstruction; Parul Natvar Patel and Charles W. Patrick Jr.
    Scaffolding in Periodontal Engineering; Orasa Anusaksathien, Qi-ming Jin, Peter X. Ma, and William V. Giannobile
    Tissue Engineering of Craniofacial Structure; Kacey G. Marra, Mark P. Mooney, and Jeffrey O. Hollinger
    Hemoglobin-Based Red Blood Cell Substitutes; Thomas M. S. Chang
    Nerve Regeneration; Erin Lavik and Robert Langer
    Functional Tissue Engineering of Cartilage and Myocardium: Bioreactor Aspects; Milica Radisic, Bojana Obradovic, and G. Vunjak-Novakovic
    Stem Cells in Tissue Engineering; Victor Prisk and Johnny Huard
    Osteochondral Tissue Engineering - Regeneration of Articular Condyle from Mesenchymal Stem Cells; Adel Alhadlaq and Jeremy J. Mao
    Tissue Engineered Meniscal Tissue; Mark A. Randolph, MAS and Thomas J. Gill
    Tissue Engineering for Insulin Replacement in Diabetes; Amy S. Lewis and Clark K. Colton
    3-D Tissue Fabrication: Application to Hepatic Tissue Engineering; Valerie A. Liu and Sangeeta N. Bhatia

    Editorial Reviews

    "The editors certainly succeeded in their purpose to produce a robust and outstanding book…Scaffolding in Tissue Engineering brought together an extraordinary amount of information related to the use of scaffolds in TE. It is unquestionably destined to be a classic book that deserves a place on the shelves of every researcher in TE and libraries. Congratulations to the editors and to all contributors for this exceptional book."
    -Eduardo Abreu, Biomedical Engineering Online, October 2006