1st Edition

Vitamin A in Health and Disease

By Rune Blomhoff Copyright 1994

    This book is intended as a source of information for the many scientists who now enter the growing research field of vitamin A in health and disease, reviewing the epidemiological aspects related to vitamin A.

    Introduction


    Overview of Vitamin A Metabolism and Function


    Metabolism of Vitamin A


    Absorption of Vitamin A
    Role of Perisinusoidal Stellate Cells in Vitamin A Storage
    The Retinol-Binding Protein Superfamily
    Dynamic and Control of Plasma Retinol
    Retinoic Acid Homeostasis: Prospective Roles of b-Carotene, Retinol, CRBP, and CRABP


    Mechanism of Action of Vitamin A and Carotenoids


    Role of Nuclear Retinoic Acid Receptors in the Regulation of Gene Expression
    The Retinoid X Receptors: Modulators of Multiple Hormonal Signaling Pathways
    Retinoylation of Proteins in Mammalian Cells
    Role of Carotenoids in Antioxidant Defense


    Embryonic Development


    Role of Retinoids in Embryonic Development
    Vitamin A in Lung Development and Bronchopulmonary Dysplasia
    Are Ethanol-Induced Birth Defects Caused by Functional Retinoic Acid Deficiency?


    Skin and Epithelial Cells


    Role of Retinoids in Normal and Diseased Skin
    Regulation of Epithelial Differentiation by Retinoids


    Blood Cells


    Role of Retinoids in Normal Hematopoiesis and the Immune System
    Retinoids and Acute Myeloid Leukemia


    Vision


    Retinoid Isomerization Reactions in the Visual System


    Reproduction


    Vitamin A Functions in the Reproductive Organs


    Intake and Cancer Incidence


    Vitamin A and Cancer: Epidemiological Evidence in Humans


    Deficiency and Toxicity


    Vitamin A Deficiency: Its Epidemiology and Relation to Child Mortality and Morbidity
    Teratogenicity of Vitamin A and Retinoids


    Requirements


    Dietary Vitamin A Requirements

    Biography

    Rune Blomhoff

    "
    …provides outstanding reviews of…research in vitamin A by an international group of excellent basic and clinical scientists…a valuable resource for basic scientists and clinicians.
    "-Doody's Health Sciences Book Review Journal