1st Edition
Synthetic Gene Network Modeling, Analysis and Robust Design Methods
This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic gene networks. Based on the system theory, some design specifications are provided to engineer the synthetic gene networks to robustly track the desired trajectory by employing the component libraries.
General introduction
Survey of synthetic gene networks
Experimental techniques for engineering synthetic gene networks
Mathematical models and design specifications in synthetic gene networks
Robust synthetic biology designs based on system dynamic methods
Construction of promoter library and RBS library for synthesis of gene networks
Robust synthetic gene network designs based on library-search method
Next-generation synthetic gene network
Biography
Bor-Sen Chen, Yu-Chao Wang
