DNA Repair and Cancer

DNA Repair and Cancer: From Bench to Clinic

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Summary

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Table of Contents

Overview of DNA Repair Pathways
Longevity Assurance by Genome Maintenance
Genome Instability of Cancer: Biological Predictions and Clinical Implications
Radiation Induced DNA Damage, Repair and Therapeutics
Chemotherapeutic Alkylating Agents in Cancer Treatment
O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy
DNA Mismatch Repair: It’s Role in Human Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy
DNA Base Excision Repair Therapeutics: Summary of Targets with a Focus on APE1
Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility
Fanconi Anemia, Interstrand Cross-link Repair and Cancer
Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets
p53 in DNA Damage, Repair and Cancer Therapeutics
ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy
The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy
PARP and PARP Inhibitor Therapeutics
Tumor Genetics and Personalized Medicine
The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment
Early Phase Clinical Trials using DNA Repair Inhibitors: Lessons Learnt

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