1st Edition

DNA Repair and Cancer From Bench to Clinic

Edited By Srinivasan Madhusudan, David M. Wilson III Copyright 2013
    718 Pages 18 Color & 56 B/W Illustrations
    by CRC Press

    DNA repair is a rapidly advancing field in biology. DNA repair systems represent a major defense mechanism against environmental and intracellular damaging agents, such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. In particular, it provides essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

    Overview of DNA Repair Pathways
    Longevity Assurance by Genome Maintenance
    Genome Instability of Cancer: Biological Predictions and Clinical Implications
    Radiation Induced DNA Damage, Repair and Therapeutics
    Chemotherapeutic Alkylating Agents in Cancer Treatment
    O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy
    DNA Mismatch Repair: It’s Role in Human Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy
    DNA Base Excision Repair Therapeutics: Summary of Targets with a Focus on APE1
    Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility
    Fanconi Anemia, Interstrand Cross-link Repair and Cancer
    Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets
    p53 in DNA Damage, Repair and Cancer Therapeutics
    ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy
    The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy
    PARP and PARP Inhibitor Therapeutics
    Tumor Genetics and Personalized Medicine
    The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment
    Early Phase Clinical Trials using DNA Repair Inhibitors: Lessons Learnt

    Biography

    Srinivasan Madhusudan, David M. Wilson III